Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vitku, J.; Starka, L.; Bicikova, M.; Hill, M.; Heracek, J.; Sosvorova, L.; Hampl, R.
    Endocrine disruptors and other inhibitors of 11beta-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition (2016), J. Steroid Biochem. Mol. Biol., 155, 207-216.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 (1E,4E)-1,5-bis(3-methylthiophen-2-yl)penta-1,4-dien-3-one
-
 Homo sapiens
1.1.1.146 (1E,4E)-1,5-bis(thiophen-2-yl)cyclohexanone
-
 Homo sapiens
1.1.1.146 (1E,4E)-1,5-bis(thiophen-2-yl)penta-1,4-dien-3-one
-
 Homo sapiens
1.1.1.146 (20R,23E)-eupha-8,23-diene-3beta,25-diol
-
 Homo sapiens
1.1.1.146 (24R)-eupha-8,25-diene-3beta,24-diol
-
 Homo sapiens
1.1.1.146 2'-hydroxyflavanone
-
 Homo sapiens
1.1.1.146 2,2'-Dihydroxybiphenyl
-
 Homo sapiens
1.1.1.146 2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane
-
 Homo sapiens
1.1.1.146 3-methylchrysazin
-
 Homo sapiens
1.1.1.146 4'-hydroxyflavanone
-
 Homo sapiens
1.1.1.146 4-n-nonylphenol
-
 Homo sapiens
1.1.1.146 4-n-octylphenol
-
 Homo sapiens
1.1.1.146 4-nonylphenol
-
 Homo sapiens
1.1.1.146 4-tert-octylphenol
-
 Homo sapiens
1.1.1.146 6-hydroxyflavanone
-
 Homo sapiens
1.1.1.146 abietic acid
-
 Homo sapiens
1.1.1.146 aloe emodin
-
 Homo sapiens
1.1.1.146 bisphenol A
-
 Homo sapiens
1.1.1.146 carbenoxolone
-
 Homo sapiens
1.1.1.146 curcumin
-
 Homo sapiens
1.1.1.146 di-n-butyl phthalate
-
 Homo sapiens
1.1.1.146 dibenzoylmethane
-
 Homo sapiens
1.1.1.146 dibutyltin
-
 Homo sapiens
1.1.1.146 dicyclohexyl benzene-1,2-dicarboxylate
-
 Homo sapiens
1.1.1.146 diethylhexyl adipate
-
 Homo sapiens
1.1.1.146 diphenyltin
-
 Homo sapiens
1.1.1.146 dipropyl phthalate
-
 Homo sapiens
1.1.1.146 Disulfiram
-
 Homo sapiens
1.1.1.146 emodin
-
 Homo sapiens
1.1.1.146 endosulfan
-
 Homo sapiens
1.1.1.146 epigallocatechine-3-gallate
-
 Homo sapiens
1.1.1.146 euphane-3beta,20-dihydroxy-24-ene
-
 Homo sapiens
1.1.1.146 flavanone
-
 Homo sapiens
1.1.1.146 Fusidic acid
-
 Homo sapiens
1.1.1.146 glycyrrhetinic acid
-
 Homo sapiens
1.1.1.146 kansenone
-
 Homo sapiens
1.1.1.146 kansuinone
-
 Homo sapiens
1.1.1.146 maneb
-
 Homo sapiens
1.1.1.146 methoxychlor
-
 Homo sapiens
1.1.1.146 methyl jasmonate
-
 Homo sapiens
1.1.1.146 mono(2-ethylhexyl)phthalate
-
 Homo sapiens
1.1.1.146 perfluorohexanesulfonate
-
 Homo sapiens
1.1.1.146 Perfluorooctanoic acid
-
 Homo sapiens
1.1.1.146 perfluorooctyl sulfonate
-
 Homo sapiens
1.1.1.146 pyrrolidine dithiocarbamate
-
 Homo sapiens
1.1.1.146 resveratrol
-
 Homo sapiens
1.1.1.146 rheochrysidin
-
 Homo sapiens
1.1.1.146 thiram
-
 Homo sapiens
1.1.1.146 tributyltin
-
 Homo sapiens
1.1.1.146 Triphenyltin
-
 Homo sapiens
1.1.1.146 zearalenone
-
 Homo sapiens
1.1.1.146 zineb
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NADP+ Homo sapiens
-
 cortisone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+ Homo sapiens
-
 cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 adipose tissue
-
 Homo sapiens
-
1.1.1.146 brain
-
 Homo sapiens
-
1.1.1.146 colon
-
 Homo sapiens
-
1.1.1.146 kidney
-
 Homo sapiens
-
1.1.1.146 placenta
-
 Homo sapiens
-
1.1.1.146 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+
-
 Homo sapiens cortisone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.146 11betaHSD1 isoform Homo sapiens
1.1.1.146 11betaHSD2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens