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Literature summary extracted from

  • Tsai, P.W.; Chien, C.Y.; Yeh, Y.C.; Tung, L.; Chen, H.F.; Chang, T.H.; Lan, C.Y.
    Candida albicans Hom6 is a homoserine dehydrogenase involved in protein synthesis and cell adhesion (2017), J. Microbiol. Immunol. Infect., 50, 863-871.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.3 drug development the enzyme might be a good target for anti-fungal drug development Candida albicans
1.1.1.3 additional information HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices Candida albicans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.3 gene HOM6, DNA and amino acid sequence determination and analysis from the strain SC5314 genome, sequence comparison, reintegration of the gene encoding the wild-type enzyme into HOM6-deletion strains Candida albicans

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.3 additional information generation of HOM6-deleted (HOM6/hom6DELT and hom6DELTA/hom6DELTA) and HOM6-reintegrated (hom6DELTA/hom6DELTA::HOM6 and hom6DELTA::HOM6/hom6DELTA::HOM6) strains Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.3 cell wall
-
 Candida albicans 5618
-
1.1.1.3 cytosol
-
 Candida albicans 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.3 L-homoserine + NADP+ Candida albicans
-
 L-aspartate 4-semialdehyde + NADPH + H+
-
 r
1.1.1.3 L-homoserine + NADP+ Candida albicans SC5314 / ATCC MYA-2876
-
 L-aspartate 4-semialdehyde + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.3 Candida albicans Q5AIA2
-
-
1.1.1.3 Candida albicans SC5314 / ATCC MYA-2876 Q5AIA2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.3 L-homoserine + NADP+
-
 Candida albicans L-aspartate 4-semialdehyde + NADPH + H+
-
 r
1.1.1.3 L-homoserine + NADP+
-
 Candida albicans SC5314 / ATCC MYA-2876 L-aspartate 4-semialdehyde + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.3 Hom6
-
 Candida albicans
1.1.1.3 orf19.2951
-
 Candida albicans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.3 30
-
 assay at Candida albicans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.3 9
-
 assay at Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.3 NADP+
-
 Candida albicans
1.1.1.3 NADPH
-
 Candida albicans

General Information

EC Number General Information Comment Organism
1.1.1.3 malfunction HOM6 deletions cause translational arrest in cells grown under amino acid starvation conditions. HOM6 deletion reduces Candida albicans cell adhesion to polystyrene, which is a common plastic used in many medical devices. HOM6-homozygous mutants are hypersensitive to hygromycin B and cycloheximide as compared with wild-type, HOM6-heterozygous, and HOM6-reintegrated strains. HOM6 deletion affects translation and leads to the accumulation of free ribosomes Candida albicans
1.1.1.3 metabolism homoserine dehydrogenase activity and is involved in the biosynthesis of methionine and threonine Candida albicans