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Literature summary extracted from

  • Wichelecki, D.; Vetting, M.; Chou, L.; Al-Obaidi, N.; Bouvier, J.; Almo, S.; Gerlt, J.
    ATP-binding cassette (ABC) transport system solute-binding protein-guided identification of novel D-altritol and galactitol catabolic pathways in Agrobacterium tumefaciens C58 (2015), J. Biol. Chem., 290, 28963-28976.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.407 1.4
-
 D-altritol pH 9.0, 25°C Agrobacterium fabrum
5.1.3.40 0.98
-
 D-tagatose 6-phosphate pH 7.9, 25°C Agrobacterium fabrum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.407 Zn2+ enzyme is a zinc-binding dehydrogenase, member of Pfam Family PF00107 Agrobacterium fabrum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.407 D-altritol + NAD+ Agrobacterium fabrum
-
 D-tagatose + NADH + H+
-
 ?
1.1.1.407 D-altritol + NAD+ Agrobacterium fabrum C58
-
 D-tagatose + NADH + H+
-
 ?
5.1.3.40 D-tagatose 6-phosphate Agrobacterium fabrum
-
 D-fructose 6-phosphate
-
 ?
5.1.3.40 D-tagatose 6-phosphate Agrobacterium fabrum C58
-
 D-fructose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.407 Agrobacterium fabrum A9CES3
-
-
1.1.1.407 Agrobacterium fabrum C58 A9CES3
-
-
5.1.3.40 Agrobacterium fabrum
-
-
-
5.1.3.40 Agrobacterium fabrum C58
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.407 D-altritol + NAD+
-
 Agrobacterium fabrum D-tagatose + NADH + H+
-
 ?
1.1.1.407 D-altritol + NAD+
-
 Agrobacterium fabrum C58 D-tagatose + NADH + H+
-
 ?
1.1.1.407 D-arabitol + NAD+
-
 Agrobacterium fabrum ? + NADH + H+
-
 ?
1.1.1.407 D-arabitol + NAD+
-
 Agrobacterium fabrum C58 ? + NADH + H+
-
 ?
1.1.1.407 D-mannitol + NAD+
-
 Agrobacterium fabrum ? + NADH + H+
-
 ?
1.1.1.407 D-mannitol + NAD+
-
 Agrobacterium fabrum C58 ? + NADH + H+
-
 ?
1.1.1.407 additional information D-altritol is oxidized at a significantly greater rate than D-mannitol and D-arabitol Agrobacterium fabrum ?
-
 ?
1.1.1.407 additional information D-altritol is oxidized at a significantly greater rate than D-mannitol and D-arabitol Agrobacterium fabrum C58 ?
-
 ?
5.1.3.40 D-tagatose 6-phosphate
-
 Agrobacterium fabrum D-fructose 6-phosphate
-
 ?
5.1.3.40 D-tagatose 6-phosphate
-
 Agrobacterium fabrum C58 D-fructose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.407 Atu3163
-
 Agrobacterium fabrum
5.1.3.40 More member of Pfam family PF08013 Agrobacterium fabrum
5.1.3.40 Tag6PK
-
 Agrobacterium fabrum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.407 1.9
-
 D-altritol pH 9.0, 25°C Agrobacterium fabrum
5.1.3.40 8.7
-
 D-tagatose 6-phosphate pH 7.9, 25°C Agrobacterium fabrum

Expression

EC Number Organism Comment Expression
5.1.3.40 Agrobacterium fabrum transcript levels are upregulated several thousandfold upon growth on D-altritol compared with D-glucose up

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.407 1.4
-
 D-altritol pH 9.0, 25°C Agrobacterium fabrum
5.1.3.40 8.9
-
 D-tagatose 6-phosphate pH 7.9, 25°C Agrobacterium fabrum