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Literature summary extracted from

  • Sahu, B.; Sun, W.; Perusek, L.; Parmar, V.; Le, Y.Z.; Griswold, M.D.; Palczewski, K.; Maeda, A.
    Conditional ablation of retinol dehydrogenase 10 in the retinal pigmented epithelium causes delayed dark adaption in mice (2015), J. Biol. Chem., 290, 27239-27247.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.315 expression in Sf9 cell Homo sapiens
1.1.1.315 expression in Sf9 cell Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.315 Homo sapiens
-
-
-
1.1.1.315 Mus musculus Q8VCH7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.315 24000
-
 substrate 11-cis-retinol, pH 7.4, 37°C Homo sapiens
1.1.1.315 81000
-
 substrate 9-cis-retinol, pH 7.4, 37°C Homo sapiens
1.1.1.315 124000
-
 substrate all-trans-retinol, pH 7.4, 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.315 11-cis-retinol + NAD+
-
 Homo sapiens 11-cis-retinal + NADH + H+
-
 ?
1.1.1.315 9-cis-retinol + NADP+
-
 Homo sapiens 9-cis-retinal + NADPH + H+
-
 ?
1.1.1.315 all-trans-retinol + NADP+
-
 Homo sapiens all-trans-retinal + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.315 RDH10
-
 Homo sapiens
1.1.1.315 RDH10
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.315 additional information no detectable activity with NADP+ Homo sapiens
1.1.1.315 additional information no detectable activity with NADP+ Mus musculus
1.1.1.315 NAD+
-
 Homo sapiens
1.1.1.315 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.315 physiological function mice with a conditional knock-out of isoform Rdh10 in retinal pigmented epithelium cells display delayed 11-cis-retinal regeneration and dark adaption after bright light illumination. Retinal function after light exposure is also delayed in Rdh10 KO mice as compared with controls. Double deletion of isoforms Rdh5 and Rdh10 in mice causes elevated 11/13-cis-retinyl ester content also seen in Rdh5-/- Rdh11-/- mice as compared with Rdh5-/- mice. Normal retinal morphology is observed in 6-month-old Rdh10 KO and Rdh5 and Rdh10 KO mice Mus musculus