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Literature summary extracted from
- The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme (2016), FEBS Lett., 590, 2776-2786.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.1.1.49 | in complex with D-glucose 6-phosphate and NADPH, hanging drop vapor diffusion method, using 30% (w/v) jeffamine ED2003 and HEPES 0.1 M pH 7.0 | Trypanosoma cruzi |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.49 | 0.0474 | - |
NADP+ | pH and temperature not specified in the publication | Trypanosoma cruzi |  |
| 1.1.1.49 | 0.21 | - |
D-glucose 6-phosphate | pH and temperature not specified in the publication | Trypanosoma cruzi | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.49 | 57500 | - |
4 * 57500, SDS-PAGE | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.49 | D-glucose 6-phosphate + NADP+ | Trypanosoma cruzi | - |
6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.49 | Trypanosoma cruzi | Q4E0B2 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.49 | - |
Trypanosoma cruzi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.49 | D-glucose 6-phosphate + NADP+ | - |
Trypanosoma cruzi | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.49 | homotetramer | 4 * 57500, SDS-PAGE | Trypanosoma cruzi |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.49 | G6PDH | - |
Trypanosoma cruzi |
| 1.1.1.49 | glucose-6-phosphate dehydrogenase | - |
Trypanosoma cruzi |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.49 | NADP+ | - |
Trypanosoma cruzi | |
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Release 2023.1 (January 2023)
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