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Literature summary extracted from

  • Belmont-Diaz, J.A.; Yoval-Sanchez, B.; Calleja-Castaneda, L.F.; Pardo Vazquez, J.P.; Rodriguez-Zavala, J.S.
    Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2) (2016), FEBS J., 283, 3637-3650.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.3 Alda-1 acts as activator at high concentrations of aldehyde Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Alda-1 acts as inhibitor at low concentrations of aldehyde Homo sapiens
1.2.1.3 NADH
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.0007
-
 propanal in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.006
-
 propanal in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.03
-
 NAD+ in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.073
-
 NAD+ in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 nickel chelating Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 propanal + NAD+ + H2O
-
 Homo sapiens propanoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH2
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.3 1.9
-
 NAD+ in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 1.9
-
 propanal in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 3.05
-
 NAD+ in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 3.05
-
 propanal in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.3 0.053
-
 NADH in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.133
-
 NADH in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.2.1.3 0.027
-
 NAD+ in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.117
-
 NAD+ in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 0.517
-
 propanal in the presence of 0.01 mM Alda-1, at pH 7.4 and 25°C Homo sapiens
1.2.1.3 3.13
-
 propanal in the absence of Alda-1, at pH 7.4 and 25°C Homo sapiens