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Literature summary extracted from

  • Koeberle, A.; Pergola, C.; Shindou, H.; Koeberle, S.C.; Shimizu, T.; Laufer, S.A.; Werz, O.
    Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis (2015), FASEB J., 29, 2439-2449.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information p38 MAPK is activated by phosphorylation. Inhibition of SCD-1 decreases the proportion of monounsaturated fatty acid-containing phospholipids and activates p38 MAPK Mus musculus
2.7.11.24 palmitate activates p38 MAPK phosphorylation and activates it Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.24 quantitative RT-PCR enzyme expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.24 additional information enzyme silencing by selective siRNA Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 additional information some monounsaturated fatty acids inhibit p38 MAPK via selective protein-lipid interactions Mus musculus
2.7.11.24 skepinone-L the specificity by which SCD-1 modulates the phospholipid composition and inhibits p38 MAPK signaling (among survival/stress pathways), thereby preventing endoplasmic reticulum stress (but not other SCD-1-dependent responses), suggests selective protein-lipid interactions Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 endoplasmic reticulum
-
 Mus musculus 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein p38 MAPK is activated by phosphorylation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 3T3-L1 cell
-
 Mus musculus
-
2.7.11.24 fibroblast
-
 Mus musculus
-
2.7.11.24 NIH-3T3 cell
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 p38 MAPK
-
 Mus musculus
2.7.11.24 p38 mitogen-activated protein kinase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.24 22
-
 assay at room temperature Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.24 7.4
-
 assay at Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.24 0.000025 0.00005 pH 7.4, 22°C Mus musculus skepinone-L

General Information

EC Number General Information Comment Organism
2.7.11.24 metabolism endoplasmic reticulum homeostasis is regulated by a network of signaling pathways which include stearoyl-CoA desaturase (SCD)-1, p38 mitogen-activated protein kinase (MAPK) and the unfolded protein response (UPR). All these pathways are located at the interface of cell cycle control and cell stress. Inhibition or silencing of SCD-1, via inhibitor CAY10566 or siRNA, specifically induces phosphorylation and activation of p38 MAPK. SCD-1 counteracts palmitate-induced endoplasmic reticulum stress by reducing p38 MAPK activation. Role of SCD-1 and p38 MAPK for neutral lipid biosynthesis, cell proliferation, and viability and insulin-dependent glucose uptake, overview Mus musculus
2.7.11.24 additional information p38 MAPK might show selective protein-lipid interactions Mus musculus
2.7.11.24 physiological function role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. During lipotoxic and cell cycle stress, prolonged activation of p38 MAPK due to SCD-1 inhibition induced endoplasmic reticulum stress, the unfolded protein response, and endoplasmic reticulum/Golgi remodeling. The negative regulation of p38 MAPK mediates the protective effects of SCD-1 on endoplasmic reticulum homeostasis under distinct stress conditions. Role of SCD-1 and p38 MAPK for neutral lipid biosynthesis, cell proliferation, and viability and insulin-dependent glucose uptake, overview Mus musculus