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Literature summary extracted from

  • Grzesiak, M.; Knapczyk-Stwora, K.; Slomczynska, M.
    The impact of flutamide on prostaglandin F2alpha synthase and prostaglandin F2alpha receptor expression, and prostaglandin F2alpha concentration in the porcine corpus luteum of pregnancy (2017), Domest. Anim. Endocrinol., 59, 81-89.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.188 gene AKR1B1, real-time PCR analysis enzyme expression Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.188 cytoplasm
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 Sus scrofa 5737
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1.1.1.188 additional information on gestation day GD90 enzyme PGFS is immunolocalized in the cytoplasm of large luteal cells only, whereas on GD108, sparse small luteal cells also display positive staining. PTGF receptor shows membranous localization within large luteal cells on both days of pregnancy. Immunohistochemic analysis of enzyme and prostaglandin F2 receptor during geestation, overview Sus scrofa
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Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Sus scrofa
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1.1.1.188 Sus scrofa Large White x Polish Landrace
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 luteal cell
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 Sus scrofa
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1.1.1.188 uterine endometrium
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 Sus scrofa
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Synonyms

EC Number Synonyms Comment Organism
1.1.1.188 prostaglandin F2alpha synthase
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 Sus scrofa

Expression

EC Number Organism Comment Expression
1.1.1.188 Sus scrofa flutamide, i.e. 2-methyl-N-[4-nitro-30-(trifluoromethyl)-phenyl]propamide, causes upregulation of enzyme PGFS mRNA and protein amount in pregnant female pigs at gestation days 90 and 108, whereas PTGF receptor protein expression is greater in both gestational periods up

General Information

EC Number General Information Comment Organism
1.1.1.188 physiological function prostaglandin F2alpha is the main luteolytic factor in pigs and its biosynthesis is catalyzed by prostaglandin F2alpha synthase, PGFS. The enzyme acts via specific seven-transmembrane G protein-coupled receptor (PTGFR) localized in large luteal cells. Intraluteal action of PGF2alpha causes a decrease in steroidogenic capacity and diminished production of progesterone. Intraluteal production of PGF2a is considered to be an important part of the luteolytic machinery Sus scrofa