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Literature summary extracted from

  • Lam, L.; Zhang, Z.; Board, P.; Xun, L.
    Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S-glutathionyl-hydroquinone reductases (2012), Biochemistry, 51, 5014-5021.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.5.7 0.0034
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 0.004
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
1.8.5.7 0.0067
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 0.012
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 0.017
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
1.8.5.7 0.034
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 0.034
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 0.035
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 0.07
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 0.13
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 0.15
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 0.19
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 0.24
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 0.35
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 0.37
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 0.39
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 0.43
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 0.84
-
glutathione pH 8.0, 23°C Escherichia coli
1.8.5.7 0.88
-
glutathione pH 8.0, 23°C Cupriavidus necator
1.8.5.7 1.2
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.7 Cupriavidus necator
-
-
-
1.8.5.7 Cupriavidus necator JMP 134-1
-
-
-
1.8.5.7 Escherichia coli P42620
-
-
1.8.5.7 Saccharomyces cerevisiae
-
-
-
1.8.5.7 Sphingobium chlorophenolicum
-
-
-
1.8.5.7 Sphingobium chlorophenolicum ATCC 29327
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Cupriavidus necator glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Escherichia coli glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Cupriavidus necator glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Escherichia coli glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + hydroxy-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Saccharomyces cerevisiae glutathione disulfide + menadiol
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Cupriavidus necator glutathione disulfide + menadiol
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Escherichia coli glutathione disulfide + menadiol
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Cupriavidus necator JMP 134-1 glutathione disulfide + menadiol
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Sphingobium chlorophenolicum glutathione disulfide + menadione
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-menadiol
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + menadione
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Saccharomyces cerevisiae glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Cupriavidus necator glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Sphingobium chlorophenolicum glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Escherichia coli glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Sphingobium chlorophenolicum ATCC 29327 glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
-
Cupriavidus necator JMP 134-1 glutathione disulfide + methyl-p-hydroquinone
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Saccharomyces cerevisiae ?
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Cupriavidus necator ?
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Sphingobium chlorophenolicum ?
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Escherichia coli ?
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Sphingobium chlorophenolicum ATCC 29327 ?
-
?
1.8.5.7 additional information several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred Cupriavidus necator JMP 134-1 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.5.7 ECM4
-
Saccharomyces cerevisiae
1.8.5.7 pcpF
-
Sphingobium chlorophenolicum
1.8.5.7 yqjG
-
Cupriavidus necator
1.8.5.7 yqjG
-
Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.5.7 4.4
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 4.6
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 4.9
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
1.8.5.7 7.1
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 7.2
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 7.5
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 8.4
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 11
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 13
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 13
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
1.8.5.7 14
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 14
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 14
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 14
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 15
-
glutathione pH 8.0, 23°C Escherichia coli
1.8.5.7 15
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 19
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 22
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 31
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 37
-
glutathione pH 8.0, 23°C Cupriavidus necator

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.8.5.7 12
-
glutathione pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 15
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 18
-
glutathione pH 8.0, 23°C Escherichia coli
1.8.5.7 21
-
glutathione pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 26
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 35
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 36
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 42
-
glutathione pH 8.0, 23°C Cupriavidus necator
1.8.5.7 56
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 91
-
2-(glutathione-S-yl)-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 130
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 160
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Cupriavidus necator
1.8.5.7 210
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 210
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Escherichia coli
1.8.5.7 410
-
2-(glutathione-S-yl)-methyl-p-hydroquinone pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 590
-
2-(glutathione-S-yl)-hydroxy-p-hydroquinone pH 8.0, 23°C Saccharomyces cerevisiae
1.8.5.7 760
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Cupriavidus necator
1.8.5.7 1200
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Escherichia coli
1.8.5.7 1400
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Sphingobium chlorophenolicum
1.8.5.7 2100
-
2-(glutathione-S-yl)-menadiol pH 8.0, 23°C Saccharomyces cerevisiae