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Literature summary extracted from
- L-proline dehydrogenases in hyperthermophilic archaea: distribution, function, structure, and application (2012), Appl. Microbiol. Biotechnol., 93, 83-93.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.5.5.2 | 4 | - |
L-proline | pH and temperature not specified in the publication | Pyrococcus horikoshii |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.5.5.2 | 42700 | - |
- |
Pyrococcus horikoshii |
| 1.5.5.2 | 55300 | - |
- |
Pyrococcus horikoshii |
| 1.5.5.2 | 440000 | - |
gel filtration | Pyrococcus horikoshii |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.5.2 | L-proline + acceptor | Pyrococcus horikoshii | - |
(S)-1-pyrroline-5-carboxylate + reduced acceptor | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.5.2 | Pyrococcus horikoshii | O59088 and O59089 | - |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.5.5.2 | 0.014 | - |
pH and temperature not specified in the publication | Pyrococcus horikoshii |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.5.2 | L-proline + acceptor | - |
Pyrococcus horikoshii | (S)-1-pyrroline-5-carboxylate + reduced acceptor | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.5.5.2 | heterooctamer | 4 * 55300 + 4 * 42700, calculated from amino acid sequence | Pyrococcus horikoshii |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.5.5.2 | L-proline dehydrogenase | - |
Pyrococcus horikoshii |
| 1.5.5.2 | ProDH1 | - |
Pyrococcus horikoshii |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.5.5.2 | 90 | - |
the enzyme is stable for 120 min at 90°C | Pyrococcus horikoshii |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.5.2 | ATP | - |
Pyrococcus horikoshii | |
| 1.5.5.2 | FAD | - |
Pyrococcus horikoshii | |
| 1.5.5.2 | FMN | - |
Pyrococcus horikoshii | |
| 1.5.5.2 | [4Fe-4S]-center | - |
Pyrococcus horikoshii | |
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Release 2023.1 (January 2023)
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