EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.98.3 | expressed in Mycobacterium bovis strain BCG | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.98.3 | (3,4-dihydroisoquinolin-2(1H)-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | (4-benzylpiperazin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | (4-methylpiperidin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylic acid | - |
Mycobacterium tuberculosis | |
1.1.98.3 | ethyl 1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylate | - |
Mycobacterium tuberculosis | |
1.1.98.3 | N,N-dimethyl-1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxamide | - |
Mycobacterium tuberculosis | |
1.1.98.3 | [4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | [4-[(4-fluorophenyl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | [4-[(methylamino)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | [4-[(pyridin-2-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | [4-[(pyridin-3-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + O2 + FAD | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + H2O2 + FADH2 | - |
? | |
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + O2 + FAD | Mycobacterium tuberculosis H37Rv | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + H2O2 + FADH2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.98.3 | Mycobacterium tuberculosis | P9WJF1 | - |
- |
1.1.98.3 | Mycobacterium tuberculosis H37Rv | P9WJF1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + O2 + FAD | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + H2O2 + FADH2 | - |
? | |
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + O2 + FAD | - |
Mycobacterium tuberculosis H37Rv | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + H2O2 + FADH2 | - |
? | |
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + resazurin + FAD | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + resorufin + FADH2 | - |
? | |
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + resazurin + FAD | - |
Mycobacterium tuberculosis H37Rv | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + resorufin + FADH2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.98.3 | decaprenylphosphoryl-beta-D-ribose oxidase | - |
Mycobacterium tuberculosis |
1.1.98.3 | DprE1 | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.98.3 | FAD | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.98.3 | 0.000054 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | [4-[(4-fluorophenyl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.00026 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | (3,4-dihydroisoquinolin-2(1H)-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.0004 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | [4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.00044 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | [4-[(pyridin-3-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.0012 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | (4-benzylpiperazin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.0017 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | (4-methylpiperidin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.0026 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | [4-[(pyridin-2-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.0036 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | ethyl 1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylate | |
1.1.98.3 | 0.021 | - |
at pH 7.5 and 22°C | Mycobacterium tuberculosis | N,N-dimethyl-1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxamide | |
1.1.98.3 | 0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 22°C | Mycobacterium tuberculosis | [4-[(methylamino)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone | |
1.1.98.3 | 0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 22°C | Mycobacterium tuberculosis | 1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylic acid |