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Literature summary extracted from

  • Cattelan, A.; Ceolotto, G.; Bova, S.; Albiero, M.; Kuppusamy, M.; De Martin, S.; Semplicini, A.; Fadini, G.P.; de Kreutzenberg, S.V.; Avogaro, A.
    NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis (2015), Vascul. Pharmacol., 70, 35-44.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.286 resveratrol resveratrol restores SIRT1 activity and NAD+ level by an AMPK-dependent mechanism Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.286 sirtinol
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine Rattus norvegicus
-
 nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.286 cardiomyocyte
-
 Rattus norvegicus
-
2.3.1.286 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine
-
 Rattus norvegicus nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 SIRT1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+ dependent on Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.3.1.286 Rattus norvegicus ischemia-reperfusion induces a transient upregulation of isoform SIRT1 up

General Information

EC Number General Information Comment Organism
2.3.1.286 malfunction NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis Rattus norvegicus