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Literature summary extracted from

  • Hunter, L.J.; Brockington, S.F.; Murphy, A.M.; Pate, A.E.; Gruden, K.; MacFarlane, S.A.; Palukaitis, P.; Carr, J.P.
    RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases (2016), Sci. Rep., 6, 23082.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.48 gene StRDR1, phylogenetic analysis, enzyme expression analysis by quantitative reverse transcriptase PCR Solanum tuberosum

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.48 additional information silencing of the transcripts of StRDR1a and StRDR1b by dsRNA hairpin transcripts, expression of silencing constructs for StRDR1 does not affect the expression of the StRDR2 or the StRDR6 genes. Gene silencing does not affect the plant susceptibility to plant viruses, potato virus Y, potato virus X, and tobacco mosaic virus Solanum tuberosum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Solanum tuberosum
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Solanum tuberosum M1C692 cv. Pentland Dell, gene StRDR1 or PGSC0003DMG400023601
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Solanum tuberosum diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDR
-
 Solanum tuberosum
2.7.7.48 RNA-dependent RNA polymerase 1
-
 Solanum tuberosum

Expression

EC Number Organism Comment Expression
2.7.7.48 Solanum tuberosum RDR1 expression is elevated following plant treatment with defensive phytohormones, StRDR1 is salicylic acid-responsive up

General Information

EC Number General Information Comment Organism
2.7.7.48 evolution the enzyme belongs to the RDR gene family, phylogenetic analysis of RDR genes present in potato and in a range of other plant species, overview Solanum tuberosum
2.7.7.48 malfunction StRDR1 transcript accumulation decreases in transgenic potato plants constitutively expressing a hairpin construct. These plants when challenged with three viruses, potato virus Y, potato virus X, and tobacco mosaic virus show no increase in the susceptibility of potato to these viruses. Suppression of StRDR1 gene expression does not increase in the susceptibility to the viruses Solanum tuberosum
2.7.7.48 physiological function cellular RNA-dependent RNA polymerases catalyze synthesis of double-stranded RNAs that can serve to initiate or amplify RNA silencing. Enzyme RDR1 contributes to basal virus resistance in several plants Solanum tuberosum