EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.47 | (2E)-3-chloropent-2-enedioic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 1-ethyl-4-nitro-1H-pyrazole-5-carboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 2,2'-(1,2,4-thiadiazole-3,5-diyldisulfanediyl)diacetic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 2,2'-(5-ethyl-5-nitrodihydropyrimidine-1,3(2H,4H)-diyl)diacetic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 2-phenylbutanedioic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]pyridine-3-carboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 2-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]-3-nitrobenzoic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 3,3'-[(phenylsulfonyl)imino]dipropanoic acid (non-preferred name) | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 3-(morpholin-4-ylmethyl)furan-2-carboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 4-(methylsulfinyl)-2-[(phenylsulfonyl)amino]butanoic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 6-(1,3,4-thiadiazol-2-ylcarbamoyl)cyclohex-3-ene-1-carboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 6-methyl-4,5,6,7-tetrahydro-1,2-benzoxazole-5,6-dicarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 6-methyl-7-oxo-6-azabicyclo[3.2.1]oct-2-ene-2,8-dicarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | 6-[(pyridin-4-ylmethyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | additional information | identification of potential inhibitors of the two isozymes A and B via a ligand- and structure-based in silico screening of a subset of the ZINC library using FLAP. The binding affinities of the most promising candidates are measured in vitro on purified O-acetylserine sulfhydrylase-A and O-acetylserine sulfhydrylase-B by a direct method that exploits the change in the cofactor fluorescence, ligand binding analysis, overview; identification of potential inhibitors of the two isozymes A and B via a ligand- and structure-based in silico screening of a subset of the ZINC library using FLAP. The binding affinities of the most promising candidates are measured in vitro on purified O-acetylserine sulfhydrylase-A and O-acetylserine sulfhydrylase-B by a direct method that exploits the change in the cofactor fluorescence, ligand binding analysis, overview | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-(furan-2-ylcarbonyl)leucine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-(furan-2-ylcarbonyl)phenylalanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-(thiophen-2-ylsulfonyl)valine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]glutamic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]leucine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | N-[(3-carboxybicyclo[2.2.1]hept-5-en-2-yl)carbonyl]glycylglycine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | [2-[3-acetyl-1-(2,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-2-yl]phenyl](hydroxy)oxoammonium | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | [3-[(2-carboxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)carbamoyl]-1-methyl-1H-pyrazol-4-yl](hydroxy)oxoammonium | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.5.1.47 | [3-[(2-carboxypiperidin-1-yl)sulfonyl]phenyl](hydroxy)oxoammonium | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.47 | O-acetyl-L-serine + hydrogen sulfide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
L-cysteine + acetate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.47 | Salmonella enterica subsp. enterica serovar Typhimurium | P0A1E3 | - |
- |
2.5.1.47 | Salmonella enterica subsp. enterica serovar Typhimurium | P29848 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.47 | O-acetyl-L-serine + hydrogen sulfide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | L-cysteine + acetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.47 | cysteine synthase A | UniProt | Salmonella enterica subsp. enterica serovar Typhimurium |
2.5.1.47 | cysteine synthase B | UniProt | Salmonella enterica subsp. enterica serovar Typhimurium |
2.5.1.47 | O-acetylserine sulfhydrylase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.5.1.47 | O-acetylserine sulfhydrylase-A | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.5.1.47 | O-acetylserine sulfhydrylase-B | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.47 | physiological function | O-acetylserine sulfhydrylase plays a key role in the adaptation of bacteria to the host environment, in the defense mechanisms to oxidative stress and in antibiotic resistance | Salmonella enterica subsp. enterica serovar Typhimurium |