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Literature summary extracted from

  • Zhang, Y.; Bharathi, S.S.; Rardin, M.J.; Uppala, R.; Verdin, E.; Gibson, B.W.; Goetzman, E.S.
    SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase (2015), PLoS ONE, 10, e0122297.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.8.9 additional information SIRT3 deacetylates and SIRT5 desuccinylates K299 which serves to stabilize the essential FAD cofactor in the active site of the enzyme Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.286 H248Y inactive Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.9 mitochondrial membrane
-
 Homo sapiens 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 NAD+ + [very long-chain acyl-CoA dehydrogenase]-N6-acetyl-L-lysine Mus musculus
-
 nicotinamide + [very long-chain acyl-CoA dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.9 Homo sapiens P49748
-
-
2.3.1.286 Mus musculus Q8R104
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.286 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.9 additional information the enzyme is a cardiolipin-binding protein Homo sapiens ?
-
 ?
1.3.8.9 palmitoyl-CoA + electron-transfer flavoprotein
-
 Homo sapiens (2E)-2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
-
 ?
2.3.1.286 NAD+ + [very long-chain acyl-CoA dehydrogenase]-N6-acetyl-L-lysine
-
 Mus musculus nicotinamide + [very long-chain acyl-CoA dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.9 very long-chain acyl-CoA dehydrogenase
-
 Homo sapiens
1.3.8.9 VLCAD
-
 Homo sapiens
2.3.1.286 SIRT3 isoform Mus musculus
2.3.1.286 SIRT5 isoform Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.9 FAD
-
 Homo sapiens