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Literature summary extracted from

  • Heyno, E.; Innocenti, G.; Lemaire, S.D.; Issakidis-Bourguet, E.; Krieger-Liszkay, A.
    Putative role of the malate valve enzyme NADP-malate dehydrogenase in H2O2 signalling in Arabidopsis (2014), Philos. Trans. R. Soc. Lond. B Biol. Sci., 369, 20130228.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.82 reduced thioredoxin
-
 Arabidopsis thaliana
1.1.1.82 thioredoxin reduced thioredoxins, TRXs, activate the NADP-dependent malate dehydrogenase Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.82 additional information two Arabidopsis thaliana nadp-mdh T-DNA insertion mutants M44 and M81 are compared with the isogenic wild-type S44 segregated from the parent heterozygous plant of M44 initially identified by PCR genotyping Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.82 chloroplast
-
 Arabidopsis thaliana 9507
-
1.1.1.82 protoplast
-
 Arabidopsis thaliana
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.82 (S)-malate + NADP+ Arabidopsis thaliana
-
 oxaloacetate + NADPH + H+
-
 ?
1.1.1.82 (S)-malate + NADP+ Arabidopsis thaliana Col-0
-
 oxaloacetate + NADPH + H+
-
 ?
1.1.1.82 additional information Arabidopsis thaliana NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH ?
-
 ?
1.1.1.82 additional information Arabidopsis thaliana Col-0 NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH ?
-
 ?
1.1.1.82 oxaloacetate + NADPH + H+ Arabidopsis thaliana
-
 (S)-malate + NADP+
-
 r
1.1.1.82 oxaloacetate + NADPH + H+ Arabidopsis thaliana Col-0
-
 (S)-malate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.82 Arabidopsis thaliana Q8H1E2
-
-
1.1.1.82 Arabidopsis thaliana Col-0 Q8H1E2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.82 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.82 (S)-malate + NADP+
-
 Arabidopsis thaliana oxaloacetate + NADPH + H+
-
 ?
1.1.1.82 (S)-malate + NADP+
-
 Arabidopsis thaliana Col-0 oxaloacetate + NADPH + H+
-
 ?
1.1.1.82 additional information NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH Arabidopsis thaliana ?
-
 ?
1.1.1.82 additional information NADPH is oxidized and oxalacetate is reduced to malate by NADP-MDH Arabidopsis thaliana Col-0 ?
-
 ?
1.1.1.82 oxaloacetate + NADPH + H+
-
 Arabidopsis thaliana (S)-malate + NADP+
-
 r
1.1.1.82 oxaloacetate + NADPH + H+
-
 Arabidopsis thaliana Col-0 (S)-malate + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.82 MDH
-
 Arabidopsis thaliana
1.1.1.82 NADP-dependent malate dehydrogenase
-
 Arabidopsis thaliana
1.1.1.82 NADP-malate dehydrogenase
-
 Arabidopsis thaliana
1.1.1.82 NADP-MDH
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.82 NADP+
-
 Arabidopsis thaliana
1.1.1.82 NADPH
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.1.1.82 malfunction Arabidopsis thaliana mutants lacking the NADP-malate dehydrogenase lose the reversible inactivation of catalase activity and the increase in H2O2 levels when exposed to high light. The mutants are slightly affected in growth and accumulate higher levels of NADPH in the chloroplast than the wild-type. Catalase activity and H2O2 levels under high light stress in Arabidopsis thaliana knockout mutants deficient for chloroplastic NADP-MDH, overview Arabidopsis thaliana
1.1.1.82 metabolism the enzyme is involved in the signalling by a H2O2 pulse in high light-stressed plants, overview The malate valve plays a crucial role in transmitting the redox state of the chloroplast to other cell compartments Arabidopsis thaliana
1.1.1.82 physiological function the malate valve plays an essential role in the regulation of catalase activity and the accumulation of a H2O2 signal by transmitting the redox state of the chloroplast to other cell compartments Arabidopsis thaliana