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Literature summary extracted from

  • Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.
    Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis (2016), Pathol. Res. Pract., 212, 365-371.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.26 glycolate + NAD+ Homo sapiens
-
 glyoxylate + NADH + H+
-
 r
1.1.1.79 D-glycerate + NAD+ Homo sapiens
-
 hydroxypyruvate + NADH + H+
-
 ?
1.1.1.79 glycolate + NADP+ Homo sapiens
-
 glyoxylate + NADPH + H+
-
 r
1.1.1.81 D-glycerate + NAD+ Homo sapiens
-
 hydroxypyruvate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.26 Homo sapiens Q9UBQ7
-
-
1.1.1.79 Homo sapiens Q9UBQ7
-
-
1.1.1.81 Homo sapiens Q9UBQ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.26 epithelium
-
 Homo sapiens
-
1.1.1.26 HT-29 cell cultured with tumor necrosis factor alpha Homo sapiens
-
1.1.1.26 intestine
-
 Homo sapiens
-
1.1.1.79 epithelium
-
 Homo sapiens
-
1.1.1.79 HT-29 cell
-
 Homo sapiens
-
1.1.1.79 HT-29 cell cultured with tumor necrosis factor alpha Homo sapiens
-
1.1.1.79 intestinal epithelial cell
-
 Homo sapiens
-
1.1.1.79 intestine
-
 Homo sapiens
-
1.1.1.79 liver
-
 Homo sapiens
-
1.1.1.81 HT-29 cell
-
 Homo sapiens
-
1.1.1.81 intestinal epithelial cell
-
 Homo sapiens
-
1.1.1.81 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.26 glycolate + NAD+
-
 Homo sapiens glyoxylate + NADH + H+
-
 r
1.1.1.79 D-glycerate + NAD+
-
 Homo sapiens hydroxypyruvate + NADH + H+
-
 ?
1.1.1.79 glycolate + NADP+
-
 Homo sapiens glyoxylate + NADPH + H+
-
 r
1.1.1.81 D-glycerate + NAD+
-
 Homo sapiens hydroxypyruvate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.26 glyoxylate reductase/hydroxypyruvate reductase
-
 Homo sapiens
1.1.1.26 GRHPR
-
 Homo sapiens
1.1.1.79 glyoxylate reductase/hydroxypyruvate reductase
-
 Homo sapiens
1.1.1.79 GRHPR
-
 Homo sapiens
1.1.1.79 GRHPR bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities Homo sapiens
1.1.1.81 GRHPR bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.26 NAD+
-
 Homo sapiens
1.1.1.26 NADH
-
 Homo sapiens
1.1.1.79 NAD+
-
 Homo sapiens
1.1.1.79 NADP+
-
 Homo sapiens
1.1.1.79 NADPH
-
 Homo sapiens
1.1.1.81 NAD+
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.26 Homo sapiens upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) by trinitrobenzenesulphonic acid, which induces experimental colitis and intestinal epithelial cell apoptosis up
1.1.1.79 Homo sapiens upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) by trinitrobenzenesulphonic acid, which induces experimental colitis and intestinal epithelial cell apoptosis up

General Information

EC Number General Information Comment Organism
1.1.1.26 malfunction enzyme deficiency is the underlying cause of primary hyperoxaluria type 2 (PH2) and leads to increased urinary oxalate levels, formation of kidney stones and renal failure. Upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis, the phenomenon also occurs in patients with Crohn's disease. Overexpression of GRHPR is accompanied by active caspase-3 and cleaved poly ADP-ribose polymerase (PARP) accumulation. Knockdown of GRHPR inhibits the accumulation of active caspase-3 and cleaved PARP in TNF-alpha treated HT-29 cells Homo sapiens
1.1.1.26 physiological function human glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a D-2 hydroxy-acid dehydrogenase that plays a critical role in the removal of the metabolic by-product glyoxylate from the liver Homo sapiens
1.1.1.79 malfunction enzyme deficiency is the underlying cause of primary hyperoxaluria type 2 (PH2) and leads to increased urinary oxalate levels, formation of kidney stones and renal failure. Upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis, the phenomenon also occurs in patients with Crohn's disease. Overexpression of GRHPR is accompanied by active caspase-3 and cleaved poly ADP-ribose polymerase (PARP) accumulation. Knockdown of GRHPR inhibits the accumulation of active caspase-3 and cleaved PARP in TNF-alpha treated HT-29 cells Homo sapiens
1.1.1.79 physiological function upregulation of glyoxylate reductase/hydroxypyruvate reductase is associated with intestinal epithelial cells apoptosis in trinitrobenzenesulfonic acid-induced colitis Homo sapiens
1.1.1.79 physiological function human glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a D-2 hydroxy-acid dehydrogenase that plays a critical role in the removal of the metabolic by-product glyoxylate from the liver Homo sapiens
1.1.1.81 physiological function upregulation of glyoxylate reductase/hydroxypyruvate reductase is associated with intestinal epithelial cells apoptosis in trinitrobenzenesulfonic acid-induced colitis Homo sapiens