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Literature summary extracted from

  • Safi, H.; Lingaraju, S.; Amin, A.; Kim, S.; Jones, M.; Holmes, M.; McNeil, M.; Peterson, S.N.; Chatterjee, D.; Fleischmann, R.; Alland, D.
    Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-alpha-D-arabinose biosynthetic and utilization pathway genes (2013), Nat. Genet., 45, 1190-1197.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.45 A35E the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels Mycobacterium tuberculosis
2.4.2.45 G165C the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.45 ethambutol
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.45 Mycobacterium tuberculosis P9WFR5
-
-
2.4.2.46 Mycobacterium tuberculosis P9WN03
-
-
2.4.2.46 Mycobacterium tuberculosis H37Rv P9WN03
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Mycobacterium tuberculosis trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.45 5-phospho-alpha-FS18 D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase
-
Mycobacterium tuberculosis
2.4.2.45 DPPR synthase
-
Mycobacterium tuberculosis
2.4.2.45 Rv3806
-
Mycobacterium tuberculosis
2.4.2.45 ubiA
-
Mycobacterium tuberculosis
2.4.2.46 AftA
-
Mycobacterium tuberculosis
2.4.2.46 arabinofuranosyltransferase
-
Mycobacterium tuberculosis
2.4.2.46 Rv3792
-
Mycobacterium tuberculosis