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Literature summary extracted from

  • Boeck, C.R.; Carbonera, L.S.; Milioli, M.E.; Constantino, L.C.; Garcez, M.L.; Rezin, G.T.; Scaini, G.; Streck, E.L.
    Mitochondrial respiratory chain and creatine kinase activities following trauma brain injury in brain of mice preconditioned with N-methyl-D-aspartate (2013), Mol. Cell. Biochem., 384, 129-137.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.2 4-hydroxymercuribenzoic acid complete inhibition at 0.01 mM Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.3.2 mitochondrion
-
 Mus musculus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.3.2 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.3.2 ATP + creatine Mus musculus
-
 ADP + phosphocreatine
-
 r
2.7.3.2 ATP + creatine Mus musculus CF-1
-
 ADP + phosphocreatine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.2 Mus musculus
-
-
-
2.7.3.2 Mus musculus CF-1
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.3.2 brain
-
 Mus musculus
-
2.7.3.2 cerebellum
-
 Mus musculus
-
2.7.3.2 cerebral cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.2 ATP + creatine
-
 Mus musculus ADP + phosphocreatine
-
 r
2.7.3.2 ATP + creatine
-
 Mus musculus CF-1 ADP + phosphocreatine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.3.2 adenosine-5'-triphosphate: creatine phosphotransferase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.3.2 37
-
 assay at, reverse reaction direction Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.3.2 7.5
-
 assay at, reverse reaction direction Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.3.2 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.3.2 malfunction 24 h after trauma brain injury (TBI) of mice preconditioned with N-methyl-D-aspartate, creatine kinase activity is augmented in the cerebral cortex. Eventhough N-methyl-D-aspartate preconditioning and TBI have similar effects on the enzyme activity, each manages its response via opposite mechanisms because the protective effects of preconditioning are unambiguous Mus musculus
2.7.3.2 physiological function creatine kinase catalyzes the reversible transfer of the phosphoryl group from phosphocreatine to ADP, regenerating ATP, and it is a major enzyme of higher eukaryotes that manages high, fluctuating energy demands to maintain cellular energy homeostasis and guarantee stable, locally buffered ATP/ADP ratios Mus musculus