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Literature summary extracted from

  • Gimenez, A.M.; Gesumaria, M.C.; Schoijet, A.C.; Alonso, G.D.; Flawia, M.M.; Racagni, G.E.; Machado, E.E.
    Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes (2015), Mol. Biochem. Parasitol., 203, 14-24.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 Triton X-100 60% increase of activity at 1 mM Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 Ca2+ inhibitory at millimolar concentrations Trypanosoma cruzi
2.7.1.67 deoxycholate complete inhibition at 0.5 mM Trypanosoma cruzi
2.7.1.67 Mg2+ inhibitory at concentrations above 5 mM Trypanosoma cruzi
2.7.1.67 additional information not affected by adenosine Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 membrane
-
 Trypanosoma cruzi 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ the optimum concentration is 3 mM Trypanosoma cruzi
2.7.1.67 additional information not affected by micromolar Ca2+ concentrations Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Trypanosoma cruzi
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Trypanosoma cruzi ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol 4 kinase
-
 Trypanosoma cruzi
2.7.1.67 PI4K
-
 Trypanosoma cruzi