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Literature summary extracted from

  • Li, Z.; Sun, C.; Zhang, T.; Mo, J.; Shi, Q.; Zhang, X.; Yuan, M.; Chen, L.; Mao, X.; Yu, R.; Zhou, X.
    Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis (2013), J. Neurochem., 125, 698-712.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.59 GGTi-2147 a potent and selective inhibitor of GGT; potent and selective inhibitor of GGT Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.59 additional information the spatiotemporal expression pattern of GGT is correlated with the synaptogenesis in vivo Rattus norvegicus
-
-
2.5.1.59 synapse GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus Rattus norvegicus 45202
-
2.5.1.59 synaptosome GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.59 geranylgeranyl diphosphate + Cdc42-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Cdc42-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus
-
 S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rac-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rac + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rac-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rac + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rap1A-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rap1A + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rap1A-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rap1A + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rho GTPase-cysteine Rattus norvegicus
-
 S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rho GTPase-cysteine Rattus norvegicus Sprague-Dawley
-
 S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.59 Rattus norvegicus P53610 subunit beta
-
2.5.1.59 Rattus norvegicus Q04631 subunit alpha
-
2.5.1.59 Rattus norvegicus Sprague-Dawley P53610 subunit beta
-
2.5.1.59 Rattus norvegicus Sprague-Dawley Q04631 subunit alpha
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.59 brain
-
 Rattus norvegicus
-
2.5.1.59 central nervous system
-
 Rattus norvegicus
-
2.5.1.59 hippocampus
-
 Rattus norvegicus
-
2.5.1.59 neuron hippocampal and cortical Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.59 geranylgeranyl diphosphate + Cdc42-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Cdc42-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Cdc42 + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rac-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rac + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rac-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rac + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rap1A-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rap1A + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rap1A-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rap1A + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rho GTPase-cysteine
-
 Rattus norvegicus S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Rho GTPase-cysteine
-
 Rattus norvegicus Sprague-Dawley S-geranylgeranyl-Rho GTPase + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.59 dimer the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.5.1.59 geranylgeranyltransferase I
-
 Rattus norvegicus
2.5.1.59 GGT
-
 Rattus norvegicus
2.5.1.59 GGTalpha
-
 Rattus norvegicus
2.5.1.59 GGTbeta
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.59 7.5
-
 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.5.1.59 malfunction downregulation or inhibition of GGT decreases synaptogenesis Rattus norvegicus
2.5.1.59 malfunction overexpression of GGTbeta promotes the linear density of post-synaptic density protein 95 (PSD 95) and synapsin 1, two major molecular markers of synaptogenesis, while downregulation or inhibition of GGT decreases synaptogenesis Rattus norvegicus
2.5.1.59 additional information the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding Rattus norvegicus
2.5.1.59 physiological function the enzyme mediates lipid modification of Rho small GTPases, such as Rho, Rac, and Cdc42, which are important for neuronal synaptogenesis. It promotes the basal and neuronal activity and brain-derived neurotrophic factor (BDNF)-induced dendritic morphogenesis of cultured hippocampal neurons and cerebellar slices. Function and mechanism of geranylgeranyltransferase I in neuronal synaptogenesis, enzyme regulation by factors that promote synaptogenesis, overview. The activities of GGT and Rac are regulated by BDNF Rattus norvegicus