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Literature summary extracted from

  • Grover, S.; Alderwick, L.J.; Mishra, A.K.; Krumbach, K.; Marienhagen, J.; Eggeling, L.; Bhatt, A.; Besra, G.S.
    Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis (2014), J. Biol. Chem., 289, 6177-6187.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.86 gene NCgl2203 or uppS2, recombinant overexpression in wild-type Corynebacterium glutamicum eliciting an increase in decaprenyl phosphate synthesis Corynebacterium glutamicum

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.86 additional information overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043 Corynebacterium glutamicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.86 2-(2-methyl-1,3-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one i.e. BTZ043. Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis. In the presence of benzothiazinones (BTZ), the bacilli accumulate decaprenyl-phosphoribose and fail to recycle decaprenyl phosphate, which results in the depletion of decaprenyl phosphate and ultimately leads to cell death. Overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043. BTZ043 targets DprE1, which is a FAD-containing oxidoreductase involved in the epimerization of decaprenyl-phosphoribose to decaprenyl-phosphoarabinose Corynebacterium glutamicum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.86 Corynebacterium glutamicum Q8NNC1 gene NCgl2203 or uppS2
-
2.5.1.86 Corynebacterium glutamicum DSM 20300 Q8NNC1 gene NCgl2203 or uppS2
-

Synonyms

EC Number Synonyms Comment Organism
2.5.1.86 Z-decaprenyl-diphosphate synthase
-
 Corynebacterium glutamicum

General Information

EC Number General Information Comment Organism
2.5.1.86 physiological function overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043 Corynebacterium glutamicum