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Literature summary extracted from

  • Libiad, M.; Yadav, P.; Vitvitsky, V.; Martinov, M.; Banerjee, R.
    Organization of the human mitochondrial hydrogen sulfide oxidation pathway (2014), J. Biol. Chem., 289, 30901-30910.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.5.4 expression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.5.4 0.32
-
 Sulfide pH 7.4, 25°C Homo sapiens
1.8.5.4 2 3 cysteine pH 7.4, 25°C Homo sapiens
1.8.5.4 22
-
 reduced glutathione pH 7.4, 25°C Homo sapiens
1.8.5.4 22
-
 homocysteine pH 7.4, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.4 sulfide + cysteine + coenzyme Q1
-
 Homo sapiens cysteine persulfide + reduced coenzyme Q1
-
 ?
1.8.5.4 sulfide + homocysteine + coenzyme Q1
-
 Homo sapiens homocysteine persulfide + reduced coenzyme Q1
-
 ?
1.8.5.4 sulfide + reduced glutathione + coenzyme Q1
-
 Homo sapiens glutathione persulfide + reduced coenzyme Q1
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.5.4 74
-
 Sulfide pH 7.4, 25°C Homo sapiens
1.8.5.4 92
-
 homocysteine pH 7.4, 25°C Homo sapiens
1.8.5.4 94
-
 cysteine pH 7.4, 25°C Homo sapiens
1.8.5.4 113
-
 reduced glutathione pH 7.4, 25°C Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.5.4 physiological function human sulfide quinone oxidoreductase uses glutathione as an acceptor forming glutathione persulfide (GSSH), which is preferentially converted to thiosulfate by human rhodanese Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.8.5.4 2.3
-
 Sulfide pH 7.4, 25°C Homo sapiens
1.8.5.4 4.1
-
 cysteine pH 7.4, 25°C Homo sapiens
1.8.5.4 4.2
-
 homocysteine pH 7.4, 25°C Homo sapiens
1.8.5.4 5.1
-
 reduced glutathione pH 7.4, 25°C Homo sapiens