EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.1.22 | analysis | simple, fast and sensitive coupled fluorometric assay that enables simultaneous determination of nicotinamide phosphoribosyltransferase EC 2.4.2.12, quinolinate phosphoribosyltransferase EC 2.4.2.19, nicotinate phosphoribosyltransferase EC 6.3.4.21 and nicotinamide riboside kinase in whole-cell extracts and biological fluids yielding an overall picture of the tissue/cell-specific distribution of the activities of the various enzymes | Homo sapiens |
2.7.1.173 | diagnostics | screening of tumors for NRK activity is necessary for the design of efficient NamPRT-targeted antitumor therapy | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.22 | Homo sapiens | - |
- |
- |
2.7.1.173 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.22 | blood plasma | - |
Homo sapiens | - |
2.7.1.22 | kidney | and liver, highest eypression | Homo sapiens | - |
2.7.1.22 | liver | and kidney, highest eypression | Homo sapiens | - |
2.7.1.22 | additional information | presence of quinolinate phosphoribosyltransferase and nicotinamide riboside kinase in all examined tissues/cell lines | Homo sapiens | - |
2.7.1.173 | brain | - |
Homo sapiens | - |
2.7.1.173 | heart | - |
Homo sapiens | - |
2.7.1.173 | kidney | - |
Homo sapiens | - |
2.7.1.173 | liver | - |
Homo sapiens | - |
2.7.1.173 | lung | - |
Homo sapiens | - |
2.7.1.173 | additional information | ubiquitous expression of nicotinamide riboside kinase in tissues and cell lines | Homo sapiens | - |
2.7.1.173 | skeletal muscle | - |
Homo sapiens | - |
2.7.1.173 | spleen | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.173 | ATP + beta-D-ribosylnicotinate | - |
Homo sapiens | ADP + nicotinate beta-D-ribonucleotide | - |
? | |
2.7.1.173 | additional information | development of a highly sensitive, rapid and specific coupled enzymatic assay that allows simultaneous determination of NRK activitiy, as well as of nicotinic acid phosphoribosyltransferase, quinolinic acid phosphoribosyltransferase, and nicotinamide phosphoribosyltransferase activities, in various biological samples of various origins, evaluation and optimization using liver extracts, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.173 | NR kinase | - |
Homo sapiens |
2.7.1.173 | Nrk | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.173 | metabolism | distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase | Homo sapiens |
2.7.1.173 | physiological function | nicotinamide riboside is a relevant NAD+ precursor | Homo sapiens |