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Literature summary extracted from

  • Mathew, B.; Ahsan, M.
    Molecular recognisation of 3a, 4-dihydro-3-H-indeno [1, 2-C] pyrazole-2-carboxamide/carbothioamide anticonvulsant analogues towards GABA-aminotransferase - an in silico approach (2014), Cent. Nerv. Syst. Agents Med. Chem., 14, 39-42.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 N-(4-bromophenyl)-3-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide molecular docking to propose the binding interaction with a three-dimensional structural model of the gamma-aminobutyric acid amino transferase. The compound successfully binds to the active pocket of the enzyme with good predicted affinities Sus scrofa
2.6.1.19 N-(4-bromophenyl)-3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide molecular docking to propose the binding interaction with a three-dimensional structural model of the gamma-aminobutyric acid amino transferase. The compound successfully binds to the active pocket of the enzyme with good predicted affinities Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Sus scrofa P80147
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.19 0.086
-
 predicted value, pH not specified in the publication, temperature not specified in the publication Sus scrofa N-(4-bromophenyl)-3-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide
2.6.1.19 0.149
-
 predicted value, pH not specified in the publication, temperature not specified in the publication Sus scrofa N-(4-bromophenyl)-3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide