Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Prunetti, L.; Graf, M.; Blaby, I.K.; Peil, L.; Makkay, A.M.; Starosta, A.L.; Papke, R.T.; Oshima, T., Wilson, D.N.; de Crécy-Lagard, V.
    Deciphering the translation initiation factor 5A modification pathway in halophilic Archaea (2016), Archaea, 2016, 7316725.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.46 expression in Escherichia coli Saccharomyces cerevisiae
2.5.1.46 expression in Escherichia coli Thermococcus kodakarensis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Haloferax volcanii
-
-
-
2.5.1.46 Haloferax volcanii LSP5021
-
-
-
2.5.1.46 Saccharomyces cerevisiae
-
-
-
2.5.1.46 Thermococcus kodakarensis
-
-
-
3.5.3.11 Haloferax volcanii D4GWG4
-
-
3.5.3.11 Haloferax volcanii DSM 3757 D4GWG4
-
-
4.1.1.19 Haloferax volcanii D4GTI7
-
-
4.1.1.19 Haloferax volcanii DSM 3757 D4GTI7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 additional information recombinant deoxyhypusine synthase from Haloferax volcanii does not show any activity under varying aIF5A concentration and substrate concentration unsing spermidine, agmatine, cadaverine, and putrescine. In vivo, the eIF5A-precursor in Haloferax volcanii is shown to be deoxyhypusinylated Haloferax volcanii ?
-
 ?
2.5.1.46 additional information recombinant deoxyhypusine synthase from Haloferax volcanii does not show any activity under varying aIF5A concentration and substrate concentration unsing spermidine, agmatine, cadaverine, and putrescine. In vivo, the eIF5A-precursor in Haloferax volcanii is shown to be deoxyhypusinylated Haloferax volcanii LSP5021 ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine42 + spermidine substrate [eIF5A-precursor]-lysine42 of Haloferax volcanii Saccharomyces cerevisiae [eIF5A-precursor]-lysine42-deoxyhypusine + propane-1,3-diamine overall reaction ?
2.5.1.46 [eIF5A-precursor]-lysine42 + spermidine substrate [eIF5A-precursor]-lysine42 of Haloferax volcanii Thermococcus kodakarensis [eIF5A-precursor]-lysine42-deoxyhypusine + propane-1,3-diamine overall reaction ?
4.1.1.19 L-arginine
-
 Haloferax volcanii agmatine + CO2
-
 ?
4.1.1.19 L-arginine
-
 Haloferax volcanii DSM 3757 agmatine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.46 HVO 2297
-
 Haloferax volcanii
3.5.3.11 HVO_2299
-
 Haloferax volcanii
3.5.3.11 SpeB
-
 Haloferax volcanii
4.1.1.19 HVO_1958
-
 Haloferax volcanii
4.1.1.19 PdaD
-
 Haloferax volcanii

General Information

EC Number General Information Comment Organism
3.5.3.11 physiological function the gene is essential, its deletion failed even in the presence of 1 mM putrescine Haloferax volcanii
4.1.1.19 physiological function a gene deletion strain is auxotrophic for agmatine and requires 5 microM agmatine for full growth. Partial growth is observed at lower agmatine concentrations, but no growth is observed below 1 microM agmatine. Polyamines such as putrescine, spermidine, cadaverine, or ornithine do not rescue the growth defect Haloferax volcanii