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Literature summary extracted from

  • Kanazawa, H.; Hoque, M.M.; Tsunoda, M.; Suzuki, K.; Yamamoto, T.; Kawai, G.; Kondo, J.; Takenaka, A.
    Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase (2016), Acta Crystallogr. Sect. F, 72, 507-515.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.30 in complex with NAD+, malonate, or methylmalonate, hanging drop vapor diffusion method, using 30-34% (w/v) PEG 4000 Alcaligenes faecalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.30 malonate
-
 Alcaligenes faecalis
1.1.1.30 methylmalonate
-
 Alcaligenes faecalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Alcaligenes faecalis
-
 acetoacetate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.30 Alcaligenes faecalis D0VWQ0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.30
-
 Alcaligenes faecalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Alcaligenes faecalis acetoacetate + NADH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.30 homotetramer x-ray crystallography Alcaligenes faecalis

Synonyms

EC Number Synonyms Comment Organism
1.1.1.30 D-3-hydroxybutyrate dehydrogenase
-
 Alcaligenes faecalis
1.1.1.30 HBDH
-
 Alcaligenes faecalis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.30 NAD+
-
 Alcaligenes faecalis