BRENDA - Enzyme Database

Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase

Kanazawa, H.; Hoque, M.M.; Tsunoda, M.; Suzuki, K.; Yamamoto, T.; Kawai, G.; Kondo, J.; Takenaka, A.; Acta Crystallogr. Sect. F 72, 507-515 (2016)

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization
Organism
1.1.1.30
in complex with NAD+, malonate, or methylmalonate, hanging drop vapor diffusion method, using 30-34% (w/v) PEG 4000
Alcaligenes faecalis
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.30
malonate
-
Alcaligenes faecalis
1.1.1.30
methylmalonate
-
Alcaligenes faecalis
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Alcaligenes faecalis
-
acetoacetate + NADH + H+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.30
Alcaligenes faecalis
D0VWQ0
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.30
-
Alcaligenes faecalis
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
737394
Alcaligenes faecalis
acetoacetate + NADH + H+
-
-
-
r
Subunits
EC Number
Subunits
Commentary
Organism
1.1.1.30
homotetramer
x-ray crystallography
Alcaligenes faecalis
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.30
NAD+
-
Alcaligenes faecalis
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.30
NAD+
-
Alcaligenes faecalis
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
1.1.1.30
in complex with NAD+, malonate, or methylmalonate, hanging drop vapor diffusion method, using 30-34% (w/v) PEG 4000
Alcaligenes faecalis
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.30
malonate
-
Alcaligenes faecalis
1.1.1.30
methylmalonate
-
Alcaligenes faecalis
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Alcaligenes faecalis
-
acetoacetate + NADH + H+
-
-
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.30
-
Alcaligenes faecalis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
737394
Alcaligenes faecalis
acetoacetate + NADH + H+
-
-
-
r
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.1.1.30
homotetramer
x-ray crystallography
Alcaligenes faecalis