EC Number | Cloned (Comment) | Organism |
---|---|---|
1.17.8.1 | expression in Escherichia coli | Rhodopseudomonas palustris |
1.17.8.1 | expression in Escherichia coli | Zymomonas mobilis |
4.2.3.156 | expression in Escherichia coli | Zymomonas mobilis |
4.2.3.156 | expression in Escherichia coli | Rhodopseudomonas palustris |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.156 | presqualene diphosphate + H2O | Zymomonas mobilis | - |
hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | Rhodopseudomonas palustris | - |
hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | Rhodopseudomonas palustris ATCC BAA-98 | - |
hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | Zymomonas mobilis ZM4 | - |
hydroxysqualene + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.8.1 | Rhodopseudomonas palustris | - |
- |
- |
1.17.8.1 | Zymomonas mobilis | Q56996 | - |
- |
4.2.3.156 | Rhodopseudomonas palustris | Q6N3F1 | - |
- |
4.2.3.156 | Rhodopseudomonas palustris ATCC BAA-98 | Q6N3F1 | - |
- |
4.2.3.156 | Zymomonas mobilis | Q5NP67 | - |
- |
4.2.3.156 | Zymomonas mobilis ZM4 | Q5NP67 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.8.1 | hydroxysqualene + FADH2 | - |
Rhodopseudomonas palustris | squalene + FAD + H2O | - |
? | |
1.17.8.1 | hydroxysqualene + FADH2 | - |
Zymomonas mobilis | squalene + FAD + H2O | - |
? | |
4.2.3.156 | additional information | no substrate: farnesyl diphosphate | Zymomonas mobilis | ? | - |
? | |
4.2.3.156 | additional information | no substrate: farnesyl diphosphate | Rhodopseudomonas palustris | ? | - |
? | |
4.2.3.156 | additional information | no substrate: farnesyl diphosphate | Rhodopseudomonas palustris ATCC BAA-98 | ? | - |
? | |
4.2.3.156 | additional information | no substrate: farnesyl diphosphate | Zymomonas mobilis ZM4 | ? | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | - |
Zymomonas mobilis | hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | - |
Rhodopseudomonas palustris | hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | - |
Rhodopseudomonas palustris ATCC BAA-98 | hydroxysqualene + diphosphate | - |
? | |
4.2.3.156 | presqualene diphosphate + H2O | - |
Zymomonas mobilis ZM4 | hydroxysqualene + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.8.1 | hpnE | - |
Rhodopseudomonas palustris |
1.17.8.1 | hpnE | - |
Zymomonas mobilis |
4.2.3.156 | hpnC | - |
Zymomonas mobilis |
4.2.3.156 | hpnC | - |
Rhodopseudomonas palustris |
4.2.3.156 | RPA3743 | - |
Rhodopseudomonas palustris |
4.2.3.156 | ZMO0869 | - |
Zymomonas mobilis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.17.8.1 | FAD | - |
Rhodopseudomonas palustris | |
1.17.8.1 | FAD | - |
Zymomonas mobilis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.8.1 | physiological function | the reactions catalyzed by HpnC-HpnE constitute a three-step route for biosynthesis of squalene from farnesyl diphosphate. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate, HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene | Rhodopseudomonas palustris |
1.17.8.1 | physiological function | the reactions catalyzed by HpnC-HpnE constitute a three-step route for biosynthesis of squalene from farnesyl diphosphate. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate, HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene | Zymomonas mobilis |
4.2.3.156 | physiological function | the gene products of HpnC, HpnD, HpnE, and HpnF are responsible for conversion of farnesyl diphosphate to hopene or related pentacyclic metabolites. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate. HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene | Rhodopseudomonas palustris |