Literature summary extracted from

Vlachogianni, I.C.; Fragopoulou, E.; Stamatakis, G.M.; Kostakis, I.K.; Antonopoulou, S.
Platelet activating factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions (2015), Prostaglandins Other Lipid Mediat., 121, 176-183.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.3.1.67	interleukin 1beta	2.5 ng/ml, induces 2fold increase in intracellular platelet activating factor levels against non-stimulated cells, as well as in the specific activity of acetyl-CoA:lyso-PAF acetyltransferase at 3 h. Effect is inhibited in presence of tyrosol or resveratrol	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.67	resveratrol	0.157 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity	Homo sapiens
2.3.1.67	tyrosol	0.048 microM, results in 50% inhibition in interleukin 1beta effect on catalytic activity	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.67	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.67	U-937 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)