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Literature summary extracted from

  • Hahn, H.G.; Choi, J.S.; Lim, H.K.; Lee, K.I.; Hwang, I.T.
    Triazolyl phenyl disulfides: 8-amino-7-oxononanoate synthase inhibitors as potential herbicides (2015), Pestic. Biochem. Physiol., 125, 78-83.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.47 agriculture 8-amino-7-oxononanoate synthase triazolyl phenyl disulfide inhibitors as potential herbicides, overview Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.47 gene bioF, recombinant expression of the enzyme in Escherichia coli strain BL21-Gold (DE) Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.47 3-([4-[(2-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 3-([4-[(3,5-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide
-
 Arabidopsis thaliana
2.3.1.47 additional information triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview Arabidopsis thaliana
2.3.1.47 N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide i.e. KHG23844, induces 2.3fold higher L-alanine accumulation in the treated Arabidopsis thaliana plants. 45-day old Arabidopsis thaliana plants are completely killed by the compound. Foliar supplement of 1 mM biotin at 1 and 2 days before KHG23844 application effectively recovers the growth inhibition of plants treated with the inhibitor Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.47 pimeloyl-[acyl-carrier protein] + L-alanine Arabidopsis thaliana
-
 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.47 Arabidopsis thaliana Q8GW43
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.47 recombinant enzyme from Escherichia coli strain BL21-Gold (DE) Arabidopsis thaliana

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.47 leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.47 pimeloyl-[acyl-carrier protein] + L-alanine
-
 Arabidopsis thaliana 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.47 7-keto-8-aminopelargonate synthase
-
 Arabidopsis thaliana
2.3.1.47 AONS
-
 Arabidopsis thaliana
2.3.1.47 KAPAS
-
 Arabidopsis thaliana

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.47 30
-
 assay at Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.47 7.5
-
 assay at Arabidopsis thaliana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.47 0.037
-
 pH 7.5, 30°C, recombinant enzyme Arabidopsis thaliana 3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide
2.3.1.47 0.055
-
 pH 7.5, 30°C, recombinant enzyme Arabidopsis thaliana 3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
2.3.1.47 0.063
-
 pH 7.5, 30°C, recombinant enzyme Arabidopsis thaliana N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide
2.3.1.47 0.07
-
 pH 7.5, 30°C, recombinant enzyme Arabidopsis thaliana 3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
2.3.1.47 0.073
-
 pH 7.5, 30°C, recombinant enzyme Arabidopsis thaliana 3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide