EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.2.3 | endosome | the enzyme later accumulates in the Golgi/endosome network | Homo sapiens | 5768 | - |
2.1.2.3 | endosome | the enzyme later accumulates in the Golgi/endosome network | Rattus norvegicus | 5768 | - |
2.1.2.3 | Golgi apparatus | the enzyme later accumulates in the Golgi/endosome network | Homo sapiens | 5794 | - |
2.1.2.3 | Golgi apparatus | the enzyme later accumulates in the Golgi/endosome network | Rattus norvegicus | 5794 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | Homo sapiens | - |
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | Rattus norvegicus | - |
tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
2.1.2.3 | additional information | Homo sapiens | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | ? | - |
? | |
2.1.2.3 | additional information | Rattus norvegicus | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Homo sapiens | P31939 | - |
- |
2.1.2.3 | Rattus norvegicus | Q6IN16 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.3 | HEK-293 cell | - |
Homo sapiens | - |
2.1.2.3 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
Rattus norvegicus | tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
2.1.2.3 | additional information | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | Homo sapiens | ? | - |
? | |
2.1.2.3 | additional information | the enzyme forms a complex with its substrate via the phosphate-binding pocket of the IMP cyclohydrolase (IMPCH) domain (residues 1-599) | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | - |
Homo sapiens |
2.1.2.3 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | - |
Rattus norvegicus |
2.1.2.3 | ATIC | - |
Homo sapiens |
2.1.2.3 | ATIC | - |
Rattus norvegicus |
2.1.2.3 | Bifunctional purine biosynthesis protein | - |
Homo sapiens |
2.1.2.3 | Bifunctional purine biosynthesis protein | - |
Rattus norvegicus |
2.1.2.3 | PurH | - |
Homo sapiens |
2.1.2.3 | PurH | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate | - |
Homo sapiens | |
2.1.2.3 | 10-formyltetrahydrofolate | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.2.3 | malfunction | insulin stimulation and enzyme ATIC knockdown readily increase the level of AMP-activated protein kinase-Thr172 phosphorylation in insulin receptor complexes. Enzyme ATIC, protein-tyrosine phosphatase-like A domain-containing protein 1, and AMP-activated protein kinase knockdown affects insulin receptor internalization in HEK-293 cells | Homo sapiens |
2.1.2.3 | malfunction | insulin stimulation and enzyme ATIC knockdown readily increase the level of AMPK-Thr172 phosphorylation in insulin receptor complexes | Rattus norvegicus |
2.1.2.3 | metabolism | last and rate-limiting enzyme of the de novo purine synthesis pathway | Homo sapiens |
2.1.2.3 | metabolism | last and rate-limiting enzyme of the de novo purine synthesis pathway | Rattus norvegicus |
2.1.2.3 | additional information | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator | Homo sapiens |
2.1.2.3 | additional information | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide is a is a potent allosteric AMPK activator. Insulin receptor autophosphorylation in isolated endosomes incubated in the presence of purified enzyme ATIC | Rattus norvegicus |
2.1.2.3 | physiological function | the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview | Homo sapiens |
2.1.2.3 | physiological function | the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase plays a central role in insulin signaling and the Golgi/endosomes protein network, compartmentalization in vivo of involved enzymes in response to insulin, kinetics of the localization, overview | Rattus norvegicus |