EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.15.15 | gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Macaca fascicularis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.15 | cholesterol + reduced adrenodoxin + O2 | Macaca fascicularis | - |
27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.15.15 | Macaca fascicularis | B8K1T2 | gene CYP27A1 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.15.15 | adrenal gland | - |
Macaca fascicularis | - |
1.14.15.15 | brain | - |
Macaca fascicularis | - |
1.14.15.15 | heart | - |
Macaca fascicularis | - |
1.14.15.15 | kidney | - |
Macaca fascicularis | - |
1.14.15.15 | liver | CYP27A1 is most abundantly expressed in liver | Macaca fascicularis | - |
1.14.15.15 | lung | - |
Macaca fascicularis | - |
1.14.15.15 | additional information | tissue expression pattern, overview | Macaca fascicularis | - |
1.14.15.15 | ovary | - |
Macaca fascicularis | - |
1.14.15.15 | small intestine | - |
Macaca fascicularis | - |
1.14.15.15 | testis | - |
Macaca fascicularis | - |
1.14.15.15 | uterus | - |
Macaca fascicularis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.15 | cholesterol + reduced adrenodoxin + O2 | - |
Macaca fascicularis | 27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.15.15 | CYP27A1 | - |
Macaca fascicularis |
1.14.15.15 | sterol 27-hydroxylase | - |
Macaca fascicularis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.15 | adrenodoxin | - |
Macaca fascicularis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.15.15 | physiological function | CYP27A1, sterol 27-hydroxylase, catalyzes the oxidation of cholesterol to 27-hydroxycholesterol in the bile acid biosynthesis and participates in other processes of cholesterol homeostasis. CYP27A1 is also involved in metabolism of vitamin D as vitamin D hydroxylase | Macaca fascicularis |