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Literature summary extracted from

  • Paulin, C.H.; Cazamea-Catalan, D.; Zilberman-Peled, B.; Herrera-Perez, P.; Sauzet, S.; Magnanou, E.; Fuentes, M.; Gothilf, Y.; Munoz-Cueto, J.A.; Falcon, J.; Besseau, L.
    Subfunctionalization of arylalkylamine N-acetyltransferases in the sea bass Dicentrarchus labrax: two-ones for one two (2015), J. Pineal Res., 59, 354-364.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.87 additional information
-
 additional information both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b Dicentrarchus labrax

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Dicentrarchus labrax A0A0K1H4R1 isoform Aanat2
-
2.3.1.87 Dicentrarchus labrax B9TU30 isoform Aanat1a
-
2.3.1.87 Dicentrarchus labrax B9TU31 isoform Aanat1b
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.87 nervous system isoforms Aanat1a and Aanat1b display a wide and distinct distribution in the nervous system and peripheral tissues Dicentrarchus labrax
-
2.3.1.87 pineal gland transcripts are detected almost exclusively in the pineal gland Dicentrarchus labrax
-
2.3.1.87 retina traces of transcripts are detected Dicentrarchus labrax
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + dopamine
-
 Dicentrarchus labrax CoA + N-acetyldopamine
-
 ?
2.3.1.87 acetyl-CoA + phenylethylamine
-
 Dicentrarchus labrax CoA + N-acetylphenylethylamine
-
 ?
2.3.1.87 acetyl-CoA + serotonin best substrate Dicentrarchus labrax CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Dicentrarchus labrax CoA + N-acetyltryptamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.87 arylalkylamine N-acetyltransferase 1a
-
 Dicentrarchus labrax
2.3.1.87 arylalkylamine N-acetyltransferase 1b
-
 Dicentrarchus labrax
2.3.1.87 arylalkylamine N-acetyltransferase 2
-
 Dicentrarchus labrax

General Information

EC Number General Information Comment Organism
2.3.1.87 physiological function Aanat1 isoforms have a broad range of functions including melatonin synthesis in the retina, and catabolism of serotonin and dopamine in the retina and other tissues Dicentrarchus labrax
2.3.1.87 physiological function isoform Aanat2 is a pineal enzyme involved in melatonin production Dicentrarchus labrax