EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.12 | 1,1-dioxo-N-[[4-[(4-pyrrolidin-1-yl-1-piperidyl)sulfonyl]-phenyl]methyl]-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine | - |
Homo sapiens | |
2.4.2.12 | 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea | - |
Homo sapiens | |
2.4.2.12 | 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide | - |
Homo sapiens | |
2.4.2.12 | FK866 | i.e. (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide | Homo sapiens | |
2.4.2.12 | GMX-1778 | i.e. (E)-1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)-guanidine | Homo sapiens | |
2.4.2.12 | N-(4-[[4-(trifluoromethyl)phenyl]sulfonyl]benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | - |
Homo sapiens | |
2.4.2.12 | N-(pyridin-4-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | N-[4-[(3,5-difluorophenyl)sulfonyl]benzyl]imidazo[1,2-a]pyridine-6-carboxamide | - |
Homo sapiens | |
2.4.2.12 | N-[4-[(6-methylpyridin-3-yl)sulfonyl]benzyl]-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxamide | - |
Homo sapiens | |
2.4.2.12 | N-[[4-(benzenesulfonyl)phenyl]methyl]-1,1-dioxo-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine | - |
Homo sapiens | |
2.4.2.12 | tert-butyl trans-1-(2-(pyridin-3-yl)cyclopropanecarbonyl)-hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate | - |
Homo sapiens | |
2.4.2.12 | tert-butyl trans-6-(2-(pyridin-3-yl)cyclopropanecarbonyl)-2,6-diazaspiro[3.4]octane-2-carboxylate | - |
Homo sapiens | |
2.4.2.12 | trans-(R,R)-N-(4-((1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-(S,S)-N-(4-((1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-(S,S)-N-(4-((1-propyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | potent inhibitor | Homo sapiens | |
2.4.2.12 | trans-2-(6-aminopyridin-3-yl)-N-(4-(phenylsulfonyl)benzyl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(6-aminopyridin-3-yl)-N-(4-(phenylsulfonyl)phenyl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(pyridin-3-yl)-N-(4-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)sulfonyl)phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(pyridin-3-yl)-N-(4-((1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)sulfonyl)phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)-sulfonyl)phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(pyridin-3-yl)-N-(4-((3-(trifluoromethyl)phenyl)-sulfonyl)phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-(pyridin-3-yl)-N-(4-((tetrahydro-2H-pyran-4-yl)-sulfonyl)phenyl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-2-phenyl-N-(pyridin-4-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-(2-Hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-ethyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-Isopropyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-isopropyl-3-methyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-isopropyl-5-methyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((1-propyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((3,5-difluorophenyl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((3-(methylsulfonyl)phenyl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-((6-methylpyridin-3-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(1-benzoylpiperidin-4-yl)butyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(morpholinosulfonyl)phenyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(phenylsulfonyl)benzyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(phenylsulfonyl)benzyl)-2-(pyridin-4-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(phenylsulfonyl)phenyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(4-(phenylsulfonyl)phenyl)-2-(pyridin-4-yl)-cyclopropanecarboxamide | - |
Homo sapiens | |
2.4.2.12 | trans-N-(6-(4-chlorophenoxy)hexyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinamide D-ribonucleotide + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.12 | Homo sapiens | P43490 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.12 | A-2780 cell | - |
Homo sapiens | - |
2.4.2.12 | HCT-116 cell | - |
Homo sapiens | - |
2.4.2.12 | HT-1080 cell | - |
Homo sapiens | - |
2.4.2.12 | MiaPaCa-2 cell | - |
Homo sapiens | - |
2.4.2.12 | PC-3 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinamide D-ribonucleotide + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.12 | Nampt | - |
Homo sapiens |
2.4.2.12 | PBEF | - |
Homo sapiens |
2.4.2.12 | pre-B-cell colony-enhancing factor | - |
Homo sapiens |
2.4.2.12 | Visfatin | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.2.12 | 0.000001 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-Isopropyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000011 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-isopropyl-5-methyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000002 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-(2-Hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000003 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea | |
2.4.2.12 | 0.0000038 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-isopropyl-3-methyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000044 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((3-(methylsulfonyl)phenyl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000047 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(1-benzoylpiperidin-4-yl)butyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.000005 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-(S,S)-N-(4-((1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000051 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-(S,S)-N-(4-((1-propyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000066 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(pyridin-3-yl)-N-(4-((1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)sulfonyl)phenyl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000072 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-propyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000076 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(6-(4-chlorophenoxy)hexyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.0000078 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(phenylsulfonyl)phenyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.0000088 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000009 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((1-ethyl-1H-pyrazol-4-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0000095 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)-sulfonyl)phenyl)cyclopropanecarboxamide | |
2.4.2.12 | 0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(pyridin-3-yl)-N-(4-((3-(trifluoromethyl)phenyl)-sulfonyl)phenyl)cyclopropanecarboxamide | |
2.4.2.12 | 0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(pyridin-3-yl)-N-(4-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)sulfonyl)phenyl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((6-methylpyridin-3-yl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-((3,5-difluorophenyl)sulfonyl)phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000021 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(morpholinosulfonyl)phenyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.000036 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(pyridin-3-yl)-N-(4-((tetrahydro-2H-pyran-4-yl)-sulfonyl)phenyl)cyclopropanecarboxamide | |
2.4.2.12 | 0.000049 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(6-aminopyridin-3-yl)-N-(4-(phenylsulfonyl)phenyl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.000062 | - |
pH and temperature not specified in the publication | Homo sapiens | 1,1-dioxo-N-[[4-[(4-pyrrolidin-1-yl-1-piperidyl)sulfonyl]-phenyl]methyl]-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine | |
2.4.2.12 | 0.000063 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[[4-(benzenesulfonyl)phenyl]methyl]-1,1-dioxo-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine | |
2.4.2.12 | 0.00046 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-(R,R)-N-(4-((1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-phenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.0013 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(phenylsulfonyl)phenyl)-2-(pyridin-4-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.0015 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(phenylsulfonyl)benzyl)-2-(pyridin-3-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.0016 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-phenyl-N-(pyridin-4-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(pyridin-4-yl)cyclopropanecarboxamide | |
2.4.2.12 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-2-(6-aminopyridin-3-yl)-N-(4-(phenylsulfonyl)benzyl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | trans-N-(4-(phenylsulfonyl)benzyl)-2-(pyridin-4-yl)-cyclopropanecarboxamide | |
2.4.2.12 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | tert-butyl trans-1-(2-(pyridin-3-yl)cyclopropanecarbonyl)-hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate | |
2.4.2.12 | 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | tert-butyl trans-6-(2-(pyridin-3-yl)cyclopropanecarbonyl)-2,6-diazaspiro[3.4]octane-2-carboxylate | |
2.4.2.12 | 0.23 | - |
pH and temperature not specified in the publication | Homo sapiens | 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide |