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Literature summary extracted from

  • Seiler, S.E.; Martin, O.J.; Noland, R.C.; Slentz, D.H.; DeBalsi, K.L.; Ilkayeva, O.R.; An, J.; Newgard, C.B.; Koves, T.R.; Muoio, D.M.
    Obesity and lipid stress inhibit carnitine acetyltransferase activity (2014), J. Lipid Res., 55, 635-644.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.7 expressed in human skeletal myocytes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 oleoyl-CoA
-
 Cavia porcellus
2.3.1.7 oleoyl-CoA
-
 Rattus norvegicus
2.3.1.7 palmitoyl-CoA direct mixed-model inhibitor Cavia porcellus
2.3.1.7 palmitoyl-CoA direct mixed-model inhibitor Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.1
-
 L-carnitine at pH 7.8 and 37°C Cavia porcellus
2.3.1.7 0.1
-
 L-carnitine at pH 7.8 and 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion
-
 Cavia porcellus 5739
-
2.3.1.7 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Cavia porcellus
-
-
-
2.3.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Cavia porcellus
2.3.1.7
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 myocyte
-
 Cavia porcellus
-
2.3.1.7 myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + L-carnitine
-
 Cavia porcellus CoA + O-acetylcarnitine
-
 r
2.3.1.7 acetyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + O-acetylcarnitine
-
 r
2.3.1.7 butyryl-CoA + L-carnitine
-
 Cavia porcellus CoA + O-butyrylcarnitine
-
 r
2.3.1.7 butyryl-CoA + L-carnitine preferred substrate Rattus norvegicus CoA + O-butyrylcarnitine
-
 r
2.3.1.7 propionyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + O-propionylcarnitine
-
 r
2.3.1.7 propionyl-CoA + L-carnitine preferred substrate Cavia porcellus CoA + O-propionylcarnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 carnitine acetyltransferase
-
 Cavia porcellus
2.3.1.7 carnitine acetyltransferase
-
 Rattus norvegicus
2.3.1.7 CRAT
-
 Cavia porcellus
2.3.1.7 CRAT
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.7 0.0306
-
 at pH 7.8 and 37°C Cavia porcellus palmitoyl-CoA
2.3.1.7 0.178
-
 at pH 7.8 and 37°C Rattus norvegicus palmitoyl-CoA

Expression

EC Number Organism Comment Expression
2.3.1.7 Cavia porcellus enzyme specific activity is diminished in muscles from obese and diabetic rodents despite increased protein abundance down
2.3.1.7 Rattus norvegicus enzyme specific activity is diminished in muscles from obese and diabetic rodents despite increased protein abundance down