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Literature summary extracted from

  • Jacobson, G.; Tanney, L.; Kelly, D.; Palman, K.; Corn, S.
    Substrate and phospholipid specificity of the purified mannitol permease of Escherichia coli (1983), J. Cell. Biochem., 23, 231-240.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.197 cardiolipin
-
Escherichia coli
2.7.1.197 phosphatidylethanolamine
-
Escherichia coli
2.7.1.197 phosphatidylglycerol
-
Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.197 2-amino-2-deoxy-D-mannitol 63% residual activity at 2 mM Escherichia coli
2.7.1.197 2-deoxy-D-mannitol 73% residual activity at 2 mM; 74% residual activity at 2 mM Escherichia coli
2.7.1.197 D-arabitol
-
Escherichia coli
2.7.1.197 D-glucitol 73% residual activity at 2 mM Escherichia coli
2.7.1.197 D-mannoheptitol 9% residual activity at 2 mM Escherichia coli
2.7.1.197 D-mannonic acid
-
Escherichia coli
2.7.1.197 additional information 1,6-dibromo-1,6-dideoxy-D-mannitol, D,L-threitol, L-threitol, erythritol, and glycerol do not inhibit the enzyme Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.197 0.01
-
D-mannitol[side 1] at pH 8.0 and 37°C Escherichia coli
2.7.1.197 0.2
-
2-amino-2-deoxy-D-mannitol[side 1] at pH 8.0 and 37°C Escherichia coli
2.7.1.197 0.5
-
2-deoxy-D-mannitol[side 1] at pH 8.0 and 37°C Escherichia coli
2.7.1.197 0.5
-
D-arabitol[side 1] Km above 0.5 mM, at pH 8.0 and 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.197 [protein]-Npi-phospho-L-histidine + D-mannitol[side 1] Escherichia coli the enzyme is highly, but not absolutely, specific for D-mannitol [protein]-L-histidine + D-mannitol 1-phosphate[side 2]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.197 Escherichia coli P00550
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.197 additional information no activity with D-galactitol, D-ribitol, and D-xylitol Escherichia coli ?
-
?
2.7.1.197 [protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-mannitol[side 1] 50% activity compared to D-mannitol Escherichia coli [protein]-L-histidine + 2-amino-2-deoxy-D-mannitol 1-phosphate[side 2]
-
?
2.7.1.197 [protein]-Npi-phospho-L-histidine + 2-deoxy-D-mannitol[side 1] 32% activity compared to D-mannitol Escherichia coli [protein]-L-histidine + 2-deoxy-D-mannitol 1-phosphate[side 2]
-
?
2.7.1.197 [protein]-Npi-phospho-L-histidine + D-arabitol[side 1] 11% activity compared to D-mannitol Escherichia coli [protein]-L-histidine + D-arabitol 1-phosphate[side 2]
-
?
2.7.1.197 [protein]-Npi-phospho-L-histidine + D-glucitol[side 1] 37% activity compared to D-mannitol Escherichia coli [protein]-L-histidine + D-glucitol 1-phosphate[side 2]
-
?
2.7.1.197 [protein]-Npi-phospho-L-histidine + D-mannitol[side 1] the enzyme is highly, but not absolutely, specific for D-mannitol Escherichia coli [protein]-L-histidine + D-mannitol 1-phosphate[side 2]
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.197 D-rnannitol-specific enzyme I1
-
Escherichia coli
2.7.1.197 mannitol permease
-
Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.197 37
-
assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.197 8
-
assay at Escherichia coli