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Literature summary extracted from

  • Tan, B.; Young, D.; Lu, Z.; Wang, T.; Meier, T.; Shepard, R.; Roth, K.; Zhai, Y.; Huss, K.; Kuo, M.; Gillig, J.; Parthasarathy, S.; Burkholder, T.; Smith, M.; Geeganage, S.; Zhao, G.
    Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications (2013), J. Biol. Chem., 288, 3500-3511.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK866 specific and potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 A-2780 cell
-
 Homo sapiens
-
2.4.2.12 BxPC-3 cell
-
 Homo sapiens
-
2.4.2.12 culture condition:McCoys 5A medium-grown cell
-
 Homo sapiens
-
2.4.2.12 DLD-1 cell
-
 Homo sapiens
-
2.4.2.12 HCC-1937 cell
-
 Homo sapiens
-
2.4.2.12 HCT-116 cell
-
 Homo sapiens
-
2.4.2.12 HT-29 cell
-
 Homo sapiens
-
2.4.2.12 MDA-MB-231 cell
-
 Homo sapiens
-
2.4.2.12 MDA-MB-468 cell
-
 Homo sapiens
-
2.4.2.12 SUM-149 cell
-
 Homo sapiens
-
2.4.2.12 SW-480 cell
-
 Homo sapiens
-
2.4.2.12 U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.12 malfunction enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition Homo sapiens
2.4.2.12 physiological function the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair Homo sapiens