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Literature summary extracted from

  • Boldrin, F.; Ventura, M.; Degiacomi, G.; Ravishankar, S.; Sala, C.; Svetlikova, Z.; Ambady, A.; Dhar, N.; Kordulakova, J.; Zhang, M.; Serafini, A.; Vishwas, K.G.; Vishwas, V.G.; Kolly, G.S.; Kumar, N.; Palu, G.; Guerin, M.E.; Mikusova, K.; Cole, S.T.; Manganelli, R.
    The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo (2014), J. Bacteriol., 196, 3441-3451.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.345 medicine PimA is required for viability during macrophage infection. In two different mouse models of infection a dramatic decrease in viable counts is observed upon silencing of the gene. Depletion of PimA results in complete clearance of the mouse lungs during both the acute and chronic phases of infection Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.345
-
Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.345 plasma membrane
-
Mycobacterium tuberculosis 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.345 Mycobacterium tuberculosis P9WMZ5
-
-
2.4.1.345 Mycobacterium tuberculosis H37Rv P9WMZ5
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.345 phosphatidyl-myo-inositol mannosyltransferase
-
Mycobacterium tuberculosis
2.4.1.345 PimA
-
Mycobacterium tuberculosis
2.4.1.345 Rv2610c
-
Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.1.57 malfunction enzyme depletion is bactericidal Mycobacterium tuberculosis
2.4.1.57 metabolism the enzyme initiates the biosynthesis of phosphatidyl-myoinositol mannosides by transferring a mannosyl residue from GDP-mannose to phosphatidyl-myo-inositol on the cytoplasmic side of the plasma membrane Mycobacterium tuberculosis
2.4.1.57 physiological function the enzyme is essential for Mycobacterium tuberculosis growth in vitro and in vivo. The enzyme is essential for growth during the acute and chronic phases of macrophage infection Mycobacterium tuberculosis
2.4.1.345 physiological function downregulation of PimA expression causes bactericidality in batch cultures associated with markedly reduced levels of phosphatidyl-myo-inositol dimannosides. PimA is required for viability during macrophage infection. In two different mouse models of infection a dramatic decrease in viable counts is observed upon silencing of the gene. Depletion of PimA results in complete clearance of the mouse lungs during both the acute and chronic phases of infection Mycobacterium tuberculosis