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Literature summary extracted from

  • Pittelli, M.; Cavone, L.; Lapucci, A.; Oteri, C.; Felici, R.; Niccolai, E.; Amedei, A.; Chiarugi, A.
    Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes (2014), Immunol. Cell Biol., 92, 191-199.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK866
-
 Homo sapiens
2.4.2.12 FK866
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Mus musculus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-
2.4.2.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 lymphocyte
-
 Mus musculus
-
2.4.2.12 lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mus musculus nicotinamide D-ribonucleotide + diphosphate
-
 ?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Mus musculus
2.4.2.12 Nampt
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.12 malfunction enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp Mus musculus
2.4.2.12 physiological function enzyme activity is essential for survival of resting lymphocytes Mus musculus
2.4.2.12 physiological function enzyme activity is essential for survival of resting lymphocytes Homo sapiens