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Literature summary extracted from

  • Setoyama, D.; Fujimura, Y.; Miura, D.
    Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells (2013), Genes Cells, 18, 1107-1119.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 arachidonic acid the enzymatic activity significantly declines by treatment with 0.1 mM for 1 h Homo sapiens
2.3.1.21 H2O2 the enzymatic activity significantly and reversibly declines by 1 mM H2O2 Homo sapiens
2.3.1.21 malonyl CoA a physiological CPT1 inhibitor Homo sapiens
2.3.1.21 rotenone the enzymatic activity significantly declines by treatment with 0.001 mM for 2 h Homo sapiens
2.3.1.21 tumor necrosis factor-alpha the enzymatic activity significantly declines by treatment with 25 ng/ml for 30 min Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 GM03440 cell
-
 Homo sapiens
-
2.3.1.21 HeLa cell
-
 Homo sapiens
-
2.3.1.21 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyltransferase-1
-
 Homo sapiens
2.3.1.21 CPT1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.21 Homo sapiens mitochondrial CPT1 proteins are targeted for inactivation by diverse oxidants or oxidative stress in human cells down

General Information

EC Number General Information Comment Organism
2.3.1.21 metabolism arnitine palmitoyltransferase-1 is the critical enzyme for mitochondrial beta-oxidation of long-chain fatty acids Homo sapiens