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Literature summary extracted from

  • Hsu, C.P.; Yamamoto, T.; Oka, S.; Sadoshima, J.
    The function of nicotinamide phosphoribosyltransferase in the heart (2014), DNA Repair, 23, 64-68.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.12 expressed in Mus musculus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 FK866
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.12 52000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Homo sapiens
2.4.2.12 PBEF
-
 Homo sapiens
2.4.2.12 pre-B-cell colony-enhancing factor
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.12 physiological function nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy Homo sapiens