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Literature summary extracted from

  • Zhao, W.; Zhou, X.; Lu, Y.; Peng, Y.; Lin, Z.; Lin, J.; Yang, L.; Yin, X.; Zhao, D.
    Mycobacterium bovis ornithine carbamoyltransferase, MB1684, induces proinflammatory cytokine gene expression by activating NF-kappaB in macrophages (2014), DNA Cell Biol., 33, 311-319.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.3.3 gene MB1684, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS Mycobacterium tuberculosis variant bovis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.3.3 39000
-
x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis
2.1.3.3 41000
-
x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis variant bovis
-
phosphate + L-citrulline
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Mycobacterium tuberculosis variant bovis P0A5M9 gene MB1684
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.3 recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3)pLysS by nickel affinity chromatography Mycobacterium tuberculosis variant bovis

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine
-
Mycobacterium tuberculosis variant bovis phosphate + L-citrulline
-
?

Subunits

EC Number Subunits Comment Organism
2.1.3.3 ? x * 39000, untagged enzyme, SDS-PAGE, x * 41000, recombinant His-tagged enzyme, SDS-PAGE Mycobacterium tuberculosis variant bovis

Synonyms

EC Number Synonyms Comment Organism
2.1.3.3 carbamoyltransferase
-
Mycobacterium tuberculosis variant bovis
2.1.3.3 MB1684
-
Mycobacterium tuberculosis variant bovis

General Information

EC Number General Information Comment Organism
2.1.3.3 physiological function the enzyme induces proinflammatory cytokine gene expression by activating NF-kappaB in macrophages of the bovine host. The enzyme plays a role in induction of upregulation of interferon-gamma and proinflammatory cytokines (interleukin-1beta, IL-6, and tumor necrosis factor-alpha) in Bos taurus Ana-1 macrophages Mycobacterium tuberculosis variant bovis