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Literature summary extracted from

  • Liang, Y.; Tian, W.; Ma, X.
    Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase (2013), BMC Complement. Altern. Med., 13, 361.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.100 grape skin extract inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 4.61 microg/ml and 20.3 microg/ml, respectively. Inhibits the overall reaction of FAS competitively with acetyl-CoA, noncompetitively with malonyl-CoA and in a mixed manner with NADPH Gallus gallus
1.1.1.100 resveratrol inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 11.1 microg/ml and 21.9 microg/ml, respectively. In 3 T3-L1 preadipocytes, resveratrol reduces lipid accumulation remarkably Gallus gallus
2.3.1.85 grape skin extract inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 4.61 microg/ml and 20.3 microg/ml, respectively. Inhibits the overall reaction of FAS competitively with acetyl-CoA, noncompetitively with malonyl-CoA and in a mixed manner with NADPH Gallus gallus
2.3.1.85 resveratrol inhibits the overall reaction and beta-ketoacyl reductase reaction of FAS with IC50 values of 11.1 microg/ml and 21.9 microg/ml, respectively. In 3 T3-L1 preadipocytes, resveratrol reduces lipid accumulation remarkably Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Gallus gallus
-
-
-
2.3.1.85 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.100 liver
-
 Gallus gallus
-
2.3.1.85 liver
-
 Gallus gallus
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.100 additional information
-
 IC50 value is 20.3 microg/ml, pH 7.0, 37°C Gallus gallus grape skin extract
1.1.1.100 additional information
-
 IC50 value is 21.9 microg/ml, pH 7.0, 37°C Gallus gallus resveratrol
2.3.1.85 additional information
-
 IC50 value is 11.1 microg/ml, pH 7.0, 37°C Gallus gallus resveratrol
2.3.1.85 additional information
-
 IC50 value is 4.61 microg/ml, pH 7.0, 37°C Gallus gallus grape skin extract