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Literature summary extracted from

  • Chen, W.; Dong, G.; He, S.; Xu, T.; Wang, X.; Liu, N.; Zhang, W.; Miao, C.; Sheng, C.
    Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (2016), Bioorg. Med. Chem. Lett., 26, 765-768.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 (2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(pyridin-3-yl)prop-2-enamide
-
 Homo sapiens
2.4.2.12 (2E)-N-[3-(1H-imidazol-1-yl)propyl]-3-(pyridin-3-yl)prop-2-enamide
-
 Homo sapiens
2.4.2.12 CHS828
-
 Homo sapiens
2.4.2.12 FK866
-
 Homo sapiens
2.4.2.12 GMX1777
-
 Homo sapiens
2.4.2.12 N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-3-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-5-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzofuran-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[2-(3,4-dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[2-(3,4-dimethoxyphenyl)ethyl]-5-nitrothiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[3-(1H-imidazol-1-yl)propyl]-1-benzofuran-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[3-(1H-imidazol-1-yl)propyl]-1-benzothiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[3-(1H-imidazol-1-yl)propyl]-3-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[3-(1H-imidazol-1-yl)propyl]-5-methylthiophene-2-carboxamide
-
 Homo sapiens
2.4.2.12 N-[3-(1H-imidazol-1-yl)propyl]-5-nitrothiophene-2-carboxamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Homo sapiens P43490
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 HCT-116 cell
-
 Homo sapiens
-
2.4.2.12 Hep-G2 cell
-
 Homo sapiens
-
2.4.2.12 MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.12 Nampt
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.12 0.00015
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
2.4.2.12 0.00017
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-5-methylthiophene-2-carboxamide
2.4.2.12 0.00086
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide
2.4.2.12 0.00095
-
 pH and temperature not specified in the publication Homo sapiens N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-5-methylthiophene-2-carboxamide
2.4.2.12 0.001
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-1-benzofuran-2-carboxamide
2.4.2.12 0.0011
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-1-benzothiophene-2-carboxamide
2.4.2.12 0.0014
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzofuran-2-carboxamide
2.4.2.12 0.0053
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[2-(3,4-dimethoxyphenyl)ethyl]-5-nitrothiophene-2-carboxamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens (2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(pyridin-3-yl)prop-2-enamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens N-(2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl)-3-methylthiophene-2-carboxamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-3-methylthiophene-2-carboxamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens N-[3-(1H-imidazol-1-yl)propyl]-5-nitrothiophene-2-carboxamide
2.4.2.12 0.01
-
 pH and temperature not specified in the publication Homo sapiens (2E)-N-[3-(1H-imidazol-1-yl)propyl]-3-(pyridin-3-yl)prop-2-enamide