EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.61 | gene zdlst, DNA and amino acid sequence determination and analysis, genetic fine-mapping, and quantitative real-time PCR enzyme expression analysis | Danio rerio |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.61 | additional information | generation of enzyme knockout mutants, the zebrafish mutant schneckentempo, phenotype ste, exhibits bradycardia. The ste mutation is a guanine to adenine nucleotide transition in the splice donor site of intron 5 of the zdlst gene, ENSDARG00000014230 | Danio rerio |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.61 | mitochondrion | the enzyme localizes to the mitochondrial matrix | Danio rerio | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.61 | succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine | Danio rerio | - |
CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.61 | Danio rerio | - |
gene zdlst | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.61 | heart | - |
Danio rerio | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.61 | succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine | - |
Danio rerio | CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.61 | dihydrolipoyl succinyltransferase | - |
Danio rerio |
2.3.1.61 | DLST | - |
Danio rerio |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.61 | malfunction | loss of dihydrolipoyl succinyltransferase leads to reduced resting heart rate in the zebrafish, enzyme deficiency causes the embryonic lethal, recessive zebrafish mutant schneckentempo ste phenotype. Homozygous ste mutants exhibit a severely reduced resting heart rate with normal atrio-ventricular conduction and contractile function. External electrical pacing reveals that defective excitation generation in cardiac pacemaker cells underlies bradycardia in ste-/- mutants. ATP levels are significantly diminished in ste-/- mutant embryos | Danio rerio |
2.3.1.61 | metabolism | dihydrolipoyl succinyltransferase catalyzes the citric acid cycle within the 2-oxoglutarate dehydrogenase complex | Danio rerio |
2.3.1.61 | physiological function | the mitochondrial enzyme dihydrolipoyl succinyltransferase is an essential player in the citric acid cycle that warrants proper ATP production. The enzyme plays an essential role in the modulation of the vertebrate heart rate by controlling ATP production in the heart | Danio rerio |