BRENDA - Enzyme Database

Roles of acyl-CoA:diacylglycerol acyltransferases 1 and 2 in triacylglycerol synthesis and secretion in primary hepatocytes

Li, C.; Li, L.; Lian, J.; Watts, R.; Nelson, R.; Goodwin, B.; Lehner, R.; Arterioscler. Thromb. Vasc. Biol. 35, 1080-1091 (2015)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.20
phosphatidylcholine
-
Mus musculus
2.3.1.20
phosphatidylethanolamine
-
Mus musculus
2.3.1.20
phosphatidylinositol
-
Mus musculus
2.3.1.20
phosphatidylserine
-
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.20
acyl-CoA + 1,2-diacyl-sn-glycerol
Mus musculus
isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol
CoA + triacylglycerol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.20
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.20
hepatocyte
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.20
acetyl-CoA + 1,2-diacetyl-sn-glycerol
-
735573
Mus musculus
CoA + triacetylglycerol
-
-
-
?
2.3.1.20
acyl-CoA + 1,2-diacyl-sn-glycerol
isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol
735573
Mus musculus
CoA + triacylglycerol
-
-
-
?
2.3.1.20
oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
735573
Mus musculus
CoA + trioleoylglycerol
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.20
phosphatidylcholine
-
Mus musculus
2.3.1.20
phosphatidylethanolamine
-
Mus musculus
2.3.1.20
phosphatidylinositol
-
Mus musculus
2.3.1.20
phosphatidylserine
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.20
acyl-CoA + 1,2-diacyl-sn-glycerol
Mus musculus
isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol
CoA + triacylglycerol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.20
hepatocyte
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.20
acetyl-CoA + 1,2-diacetyl-sn-glycerol
-
735573
Mus musculus
CoA + triacetylglycerol
-
-
-
?
2.3.1.20
acyl-CoA + 1,2-diacyl-sn-glycerol
isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol
735573
Mus musculus
CoA + triacylglycerol
-
-
-
?
2.3.1.20
oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
735573
Mus musculus
CoA + trioleoylglycerol
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.3.1.20
malfunction
Isoform DGAT1 inactivation promotes large lipid droplet formation. Inhibition of isoform DGAT2 augments fatty acid oxidation, whereas inhibition of DGAT1 increases triacylglycerol secretion. Triacylglycerol secretion is significantly reduced on DGAT2 inhibition without altering extracellular apolipoprotein B levels
Mus musculus
2.3.1.20
metabolism
the triacylglycerol pool generated by DGAT1 is preferentially used for supplying substrates for oxidation, whereas DGAt2-derived triacylglycerol is more favored for secretion
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.3.1.20
malfunction
Isoform DGAT1 inactivation promotes large lipid droplet formation. Inhibition of isoform DGAT2 augments fatty acid oxidation, whereas inhibition of DGAT1 increases triacylglycerol secretion. Triacylglycerol secretion is significantly reduced on DGAT2 inhibition without altering extracellular apolipoprotein B levels
Mus musculus
2.3.1.20
metabolism
the triacylglycerol pool generated by DGAT1 is preferentially used for supplying substrates for oxidation, whereas DGAt2-derived triacylglycerol is more favored for secretion
Mus musculus