EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.97 | expression in Escherichia coli | Aspergillus fumigatus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.3.1.97 | in complex with inhibitors 2,6-dichloro-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-(1,5-dimethyl-3-isobutyl-1H-pyrazol-4-yl)benzenesulfonamide and 2,6-dichloro-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide binding in the peptide substrate pocket | Aspergillus fumigatus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.97 | 2,6-dichloro-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-(1,5-dimethyl-3-isobutyl-1H-pyrazol-4-yl)benzenesulfonamide | inhibits the enzyme and is fungicidal under partially repressive nmt conditions | Aspergillus fumigatus | |
2.3.1.97 | 2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Aspergillus fumigatus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.97 | 0.0008 | - |
myristoleoyl-CoA | pH not specified in the publication, temperature not specified in the publication | Aspergillus fumigatus | |
2.3.1.97 | 0.022 | - |
CAP5.5 | pH not specified in the publication, temperature not specified in the publication | Aspergillus fumigatus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.97 | Aspergillus fumigatus | Q9UVX3 | - |
- |
2.3.1.97 | Aspergillus fumigatus ATCC MYA-4609 | Q9UVX3 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.97 | myristoleoyl-CoA + CAP5.5 | acceptor is biotin-tagged cytoskeleton-associated protein 5.5 | Aspergillus fumigatus | N-myristoleoyl-CAP5.5 + CoA | - |
? | |
2.3.1.97 | myristoleoyl-CoA + CAP5.5 | acceptor is biotin-tagged cytoskeleton-associated protein 5.5 | Aspergillus fumigatus ATCC MYA-4609 | N-myristoleoyl-CAP5.5 + CoA | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.97 | 0.000012 | - |
pH not specified in the publication, temperature not specified in the publication | Aspergillus fumigatus | 2,6-dichloro-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-(1,5-dimethyl-3-isobutyl-1H-pyrazol-4-yl)benzenesulfonamide | |
2.3.1.97 | 0.000023 | - |
pH not specified in the publication, temperature not specified in the publication | Aspergillus fumigatus | 2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.97 | physiological function | expression of the Nmt gene is essential for viability. Partial repression of the gene reveals downstream effects of N-myristoylation on cell wall morphology | Aspergillus fumigatus |