BRENDA - Enzyme Database show

Arsenic (+3 oxidation state) methyltransferase is a specific but replaceable factor against arsenic toxicity

Tokumoto, M.; Kutsukake, N.; Yamanishi, E.; Katsuta, D.; Anan, Y.; Ogra, Y.; Toxicol. Rep. 1, 589-595 (2014)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.1.1.137
expressed in Escherichia coli DH10B cells
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
Homo sapiens
-
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
Q9HBK9
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.1.1.137
nickel affinity His GraviTrap column chromatography
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
Hep-G2 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
additional information
the enzyme does not methylate selenium and tellurium
735309
Homo sapiens
?
-
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
735309
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
735309
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.1.137
expressed in Escherichia coli DH10B cells
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
Homo sapiens
-
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.1.137
nickel affinity His GraviTrap column chromatography
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
Hep-G2 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
additional information
the enzyme does not methylate selenium and tellurium
735309
Homo sapiens
?
-
-
-
-
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
735309
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
735309
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?