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Literature summary extracted from

  • Oskarsson, A.; Spatafora, C.; Tringali, C.; Andersson, A.O.
    Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs (2014), Prostate, 74, 839-851.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 3,5,4'-triacetylresveratrol
-
 Homo sapiens
1.14.14.19 3,5,4'-trimethylresveratrol inhibition by is more selective on the 17,20-lyase activity than hydroxylase activity of CYP17A1 Homo sapiens
1.14.14.19 3,5-diacetylresveratrol
-
 Homo sapiens
1.14.14.19 additional information not inhibited by piceatannol Homo sapiens
1.14.14.19 resveratrol i.e. trans-3,5,4'-trihydroxystilbene Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens P05093
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 NCI-H295R cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 CYP17A1
-
 Homo sapiens
1.14.14.19 cytochrome P450 17alpha-hydroxylase/17,20-lyase
-
 Homo sapiens