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Literature summary extracted from

  • Giffin, M.M.; Raab, R.W.; Morganstern, M.; Sohaskey, C.D.
    Mutational analysis of the respiratory nitrate transporter NarK2 of Mycobacterium tuberculosis (2012), PLoS ONE, 7, e45459.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.3.2.4 expressed in Escherichia coli Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
7.3.2.4 A145G the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 A92G the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 C309S the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 C378S the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 D267G the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 F114S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 F19S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 G131S inactive Mycobacterium tuberculosis
7.3.2.4 G140S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 G315S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 G69S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 G70P the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 G89S the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 I118L the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 L8V the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 P50S the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 P84T the mutant shows reduced activity compared to the wild type enzyme Mycobacterium tuberculosis
7.3.2.4 R129S the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 R259G inactive Mycobacterium tuberculosis
7.3.2.4 R58S inactive Mycobacterium tuberculosis
7.3.2.4 T78S the mutant shows wild type activity Mycobacterium tuberculosis
7.3.2.4 Y215S inactive Mycobacterium tuberculosis
7.3.2.4 Y97S the mutant shows wild type activity Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.3.2.4 oxygen
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.3.2.4 ATP + H2O + nitrate/out Mycobacterium tuberculosis
-
 ADP + phosphate + nitrate/in
-
 ?
7.3.2.4 ATP + H2O + nitrate/out Mycobacterium tuberculosis H37Rv
-
 ADP + phosphate + nitrate/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.3.2.4 Mycobacterium tuberculosis P9WJY7
-
-
7.3.2.4 Mycobacterium tuberculosis H37Rv P9WJY7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.3.2.4 ATP + H2O + nitrate/out
-
 Mycobacterium tuberculosis ADP + phosphate + nitrate/in
-
 ?
7.3.2.4 ATP + H2O + nitrate/out
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + nitrate/in
-
 ?
7.3.2.4 additional information NarK2 does not function as a nitrate/nitrite antiporter Mycobacterium tuberculosis ?
-
 ?
7.3.2.4 additional information NarK2 does not function as a nitrate/nitrite antiporter Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.3.2.4 NarK2
-
 Mycobacterium tuberculosis
7.3.2.4 type I H+/nitrate symporter
-
 Mycobacterium tuberculosis